FlyBase Allele Report: Dmel\E(spl)m8-HLH[rv1]

General Information

Symbol

Dmel\E(spl)m8-HLH^rv1

Species

D. melanogaster

Name

FlyBase ID

FBal0028166

Feature type

allele

Associated gene

Dmel\E(spl)m8-HLH

Associated Insertion(s)

Carried in Construct

Also Known As

E(spl)^R1, E(spl)^rv1

Key Links

Allele class

Mutagen

X ray

Nature of the Allele

Allele class

Mutagen

X ray

Progenitor genotype

E(spl)m8-HLH¹

(de Celis et al., 1991, Mari-Beffa et al., 1991)

Caused by aberration

In(3R)E(spl)^rv1

Cytology

Description

Deletion.

(Mari-Beffa et al., 1991)

Large deletion.

(de Celis et al., 1991)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | embryonic stage

(Park et al., 2011)

lethal | recessive

(de Celis et al., 1991)

lethal - all die during embryonic stage | neurogenic phenotype | recessive

(Lehmann et al., 1983)

some die during embryonic stage | recessive

(Lehmann et al., 1983)

Phenotype Manifest In

embryonic/larval corpus cardiacum

(Park et al., 2011)

embryonic epidermis

(Lehmann et al., 1983)

embryonic neuroblast | increased number

(Buescher et al., 2002)

larval somatic muscle cell

(Rusconi and Corbin, 1998)

larval somatic muscle cell | germline clone

(Rusconi and Corbin, 1998)

Detailed Description

Statement

Reference

The number of corpora cardiaca cells is increased in mutant stage 17 embryos compared to wild type.

(Park et al., 2011)

Additional neuroblasts are found in each position where the S1 neuroblasts normally form in mutant embryos.

(Buescher et al., 2002)

The number of cells in the nau-expressing muscle precursor clusters is increased compared to wild-type in homozygous embryos and in homozygous embryos derived from homozygous female germline clones (lacking both maternal and zygotic function).

(Rusconi and Corbin, 1998)

E(spl)^rv1 shows severe neural hypertrophy, a 6--9 fold increase in nau expressing cells per cluster relative to wild type. The clusters enlarge so much that they merge to form superclusters across the midline.

(Corbin et al., 1991)

Extreme embryonic neurogenic phenotype. Only remaining epidermis is indicated by a patch of cuticle in which a posterior spiracle and the remains of the pharynx are evident.

(Lehmann et al., 1983)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

E(spl)m8-HLH^rv1/E(spl)m8-HLH[+] is an enhancer of visible phenotype of Scer\GAL4^Tub.PU, csw^N308D.UASp

(Oishi et al., 2006)

Suppressor of

Statement

Reference

E(spl)m8-HLH^rv1 is a suppressor of short lived phenotype of Hsap\TARDBP^UAS.cHa, Scer\GAL4^Toll-6-D42

(Zhan et al., 2013)

Phenotype Manifest In

Enhancer of

Statement

Reference

E(spl)m8-HLH^rv1/E(spl)m8-HLH[+] is an enhancer of wing vein | ectopic phenotype of Scer\GAL4^Tub.PU, csw^N308D.UASp

(Oishi et al., 2006)

Additional Comments

Genetic Interactions

Statement

Reference

E(spl)^rv1 SoxN^GA1192 double mutant embryos show a combination of the neurogenic E(spl)^rv1 phenotype and the anti-neural SoxN^GA1192 phenotype. The neurogenic phenotype is apparent in the ventral column of the S1 neuroblasts. In the lateral column, the anti-neural phenotype of SoxN^GA1192 remains unchanged in the double mutant embryos.

(Buescher et al., 2002)

E(spl)^rv1 gro^unspecified Egfr^t1/Egfr^f11 and E(spl)^rv1 gro^unspecified Egfr^E3/Egfr^E3 flies show a simple additive phenotype.

(Diaz-Benjumea and Garcia-Bellido, 1990)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

199

In(3R)E(spl)^rv1, E(spl)m8-HLH^rv1/TM6B, Tb¹

Kyoto

105783

E(spl)m8-HLH^rv1/TM6B, Tb¹

Notes on Origin

Discoverer

Revertant.

Comments

Identification: Isolated by X-ray mutagenesis of E(spl)¹ followed by screening for loss of ability to enhance N^spl-1.

(Lehmann et al., 1983)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

E(Spl)^rv1

(Zhan et al., 2013)

E(spl)^R1

(Oishi et al., 2006, Buescher et al., 2002, Rusconi and Corbin, 1998, Corbin et al., 1991, de Celis et al., 1991, Mari-Beffa et al., 1991, Diaz-Benjumea and Garcia-Bellido, 1990, Lehmann et al., 1983)

E(spl)^RI

(D'Alessio and Frasch, 1996)

E(spl)^rv1

(Park et al., 2011, Babaoglan et al., 2009)

E(spl)m8-HLH^rv1

Name Synonyms

Secondary FlyBase IDs

FBal0029661

References (18)

Report Sections

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