FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\eagsc29
Open Close
General Information
Symbol
Dmel\eagsc29
Species
D. melanogaster
Name
FlyBase ID
FBal0028172
Feature type
allele
Associated gene
Dmel\eag
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

loss of function allele

amorphic allele - genetic evidence

Mutagen
    Nature of the Allele
    Allele class

    amorphic allele - genetic evidence

    (Hevers and Hardie, 1995, Griffith et al., 1994)

    loss of function allele

    (Zhong and Wu, 1993)
    Mutagen
    Progenitor genotype
    Caused by aberration
    In(1)sc29
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Homozygous adults show a reduced response to propionic acid, ethyl butyrate and 2-butanone in an electroantennogram assay compared to control flies. The response to butanol, 1-octanol, benzaldehyde, butyl acetate and 2-heptanone in this assay is not significantly different from the response of control flies to these odorants. Mutant flies have fewer antennal neurons that are sensitive to ethyl butyrate than control flies. The proportion of antennal olfactory neurons that are responsive to membrane-permeant cyclic nucleotide analogues (8-Br-cAMP and 8-Br-cGMP) is also reduced in mutant flies compared to wild-type.

        (Dubin et al., 1998)

        Application of serotonin failed to alter modulation of the channel in a semi-intact preparation of the retina.

        (Hevers and Hardie, 1995)

        Homozygotes show increased sensitivity to chloroform, but not to trichloroethylene and halothane in an inebriometer assay (an assay of geotactic and postural behaviour) compared to wild-type flies.

        (Leibovitch et al., 1995)

        Ether induced leg shaking and electrophysiological defect characteristic of eag mutations.

        (Drysdale et al., 1991)

        Mutant photoreceptors have apparently normal IA, IKs and IKf currents.

        (Hardie, 1991)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (2)
        Notes on Origin
        Discoverer

        Agol, 1930.

        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        References (18)