FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Applhs.PL
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General Information
Symbol
Dmel\Applhs.PL
Species
D. melanogaster
Name
heat shock construct of Luo
FlyBase ID
FBal0028991
Feature type
allele
Associated gene
Dmel\Appl
Associated Insertion(s)
Carried in Construct
P{hs-Appl}
Key Links
Transgenic product class
cDNA
(Luo et al., 1990)
wild_type
(Luo et al., 1990)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Luo et al., 1990)
wild_type
(Luo et al., 1990)
Mutagen
in vitro construct
(Luo et al., 1992, Tully et al., 1992, Luo et al., 1990)
Progenitor genotype
Carried in construct
P{hs-Appl}
Cytology
Description

Heat-inducible Hsp70 promoter fused to Appl cDNA.

(Luo et al., 1990)
Allele components
Component
Use(s)
Regulatory region(s)
Hsp70
Encoded product / tool
Appl
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      Applhs.PL partially rescues Appld

      (Luo et al., 1992)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      After heat shock induction ubiquitous Appl expression was seen, even in the salivary glands. Appl immunoreactivity is strongest in the nuclear region, ER and golgi apparatus localization. These results indicate that Appl is a membrane protein that is rapidly converted into a secreted form.

      (Luo et al., 1990)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Applhs.PL
      Name Synonyms
      heat shock construct of Luo
      (Luo et al., 1990)
      Secondary FlyBase IDs
        References (4)