FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Gpdh1ACyg22
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General Information
Symbol
Dmel\Gpdh1ACyg22
Species
D. melanogaster
Name
FlyBase ID
FBal0029809
Feature type
allele
Associated gene
Dmel\Gpdh1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
natural population
(Gibson et al., 1991)
Progenitor genotype
Cytology
Description

Amino acid replacement: N13Y. Amino acid replacement: R272C.

(Reed and Gibson, 1994)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
sequence_variant
2L:5,944,149..5,944,149 [+]
Nucleotide change:

A6021T

Amino acid change:

N14Y | Gpdh1-PA; N14Y | Gpdh1-PB; N14Y | Gpdh1-PC; N14Y | Gpdh1-PE; N14Y | Gpdh1-PF; N14Y | Gpdh1-PG

Comment:

Low activity variant. One of two amino acid changes in variant; thought to be the less likely of the two to cause the low activity phenotype.

(Reed and Gibson, 1994)
sequence_variant
2L:5,947,029..5,947,029 [+]
Nucleotide change:

C8901T

Reported nucleotide change:

C3977T

Amino acid change:

R272C | Gpdh1-PA; R272C | Gpdh1-PB; R272C | Gpdh1-PC; R272C | Gpdh1-PE; R272C | Gpdh1-PF; R272C | Gpdh1-PG

Comment:

Low activity variant. One of two amino acid changes; thought to be the more likely of the two to cause the low activity phenotype.

(Reed and Gibson, 1994)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
X61223
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous GpdhACyg22 flies and GpdhACyg22/Df(2L)GpdhA flies have reduced Gpdh enzyme activity compared to wild-type. Fast electrophoretic variant.

      (Gibson et al., 1991)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Isolated from: Cygnet, Tasmania population, 1984.

      (Gibson et al., 1991)
      External Crossreferences and Linkouts ( 1 )
      Crossreferences
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Gpdh1ACyg22
      GpdhACyg22
      GpdhCyg22
      (Gibson et al., 1991)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)