FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\HdcP211
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General Information
Symbol
Dmel\HdcP211
Species
D. melanogaster
Name
FlyBase ID
FBal0029838
Feature type
allele
Associated gene
Dmel\Hdc
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Immediately after lights-off, both the wild-type and HdcP211 mutant electroretinograms start a sharp recovery, but soon the mutant lags behind to wild-type. This phenotype is much diminished after a 0.2-second pulse of light compared to a 3-second pulse. Indeed, in the majority of cases, the individual mutant flies that display slow termination kinetics after a long pulse have a faster repolarization after a short pulse.

        (Rajaram et al., 2005)

        On/off transients of ERG are missing.

        (Burg et al., 1993)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        HdcP211 is rescued by Hdchs.P

        (Burg et al., 1993)
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        Comments
        Comments

        Induced by chemical mutagenesis. Mutants consistently show very low levels (10-fold less than wild type) of histamine synthesis.

        (Burg et al., 1993)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        HdcP211
        hdcP211
        (Oh et al., 2013, Melzig et al., 1998, Burg et al., 1993, Sarthy et al., 1991)
        Name Synonyms
        Secondary FlyBase IDs
          References (5)