FB2026_02 , released June 18, 2026
Allele: Dmel\Rh4ninaE.P
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General Information
Symbol
Dmel\Rh4ninaE.P
Species
D. melanogaster
Name
FlyBase ID
FBal0030115
Feature type
allele
Associated gene
Dmel\Rh4
Associated Insertion(s)
Carried in Construct
P{Rh1+4}
Key Links
Transgenic product class
wild_type
(Feiler et al., 1992)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Feiler et al., 1992)
Mutagen
in vitro construct
(Ranganathan et al., 1994, Feiler et al., 1992, Colley et al., 1991)
Progenitor genotype
Carried in construct
P{Rh1+4}
Cytology
Description

Entire gene and upstream sequences of Rh4 are fused to 2.8kb ninaE promoter fragment containing 67 nucleotides of untranslated leader sequence.

(Feiler et al., 1992)
Allele components
Component
Use(s)
Regulatory region(s)
ninaE
Encoded product / tool
Rh4
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Whole cell patch clamp recordings of P{Rh1+4}; ninaE17 photoreceptors demonstrates light-dependent changes in intracellular calcium result from the influx of external calcium. Application of thapsigargin results in a steady increase of intracellular calcium (demonstrating the existance of IP3-sensitive stores of calcium). Even after complete depletion of calcium the light response is not abolished. Instead the rise in intracellular calcium is associated with a partial desensitisation (adaptation) of the electrical response. There is no functional link between average intracellular calcium and adaptation recovery mechanisms. Localised intracellular calcium drives aspects of photoreceptor cell regulation.

      (Ranganathan et al., 1994)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of Rh4ninaE.P rescues the ability of ninaE17 larvae to strongly discriminate between 18[o]C and 24[o]C in a binary choice thermotaxis assay.

      (Shen et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      A UV sensitive rhodopsin transgene.

      (Ranganathan et al., 1994)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Rh4Rh1+4
      Rh4ninaE.P
      Name Synonyms
      Secondary FlyBase IDs
        References (7)