FlyBase Allele Report: Dmel\Scr[hs.PZ]

General Information

Symbol

Dmel\Scr^hs.PZ

Species

D. melanogaster

Name

heat shock construct of Zeng

FlyBase ID

FBal0030209

Feature type

allele

Associated gene

Dmel\Scr

Associated Insertion(s)

Carried in Construct

P{HS-Scr.Z}

Also Known As

HS-SCR

Key Links

Transgenic product class

cDNA

(Zeng et al., 1993)

wild_type

(Zeng et al., 1993)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Zeng et al., 1993)

wild_type

(Zeng et al., 1993)

Mutagen

in vitro construct

(Jullien et al., 1997, Zeng et al., 1993, Roder et al., 1992)

Progenitor genotype

Carried in construct

P{HS-Scr.Z}

Cytology

Description

An Hsp70 promoter drives expression of a cDNA that includes the entire open reading frame of Scr.

(Zeng et al., 1993)

Allele components

Component

Use(s)

Regulatory region(s)

Hsp70

Encoded product / tool

Scr

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | heat sensitive

(Zeng et al., 1993)

Phenotype Manifest In

adult head | heat sensitive

(Zeng et al., 1993)

arista | heat sensitive

(Zeng et al., 1993)

embryonic/larval salivary gland | ectopic | embryonic stage

(Andrew et al., 1994)

embryonic/larval salivary gland | ectopic | embryonic stage | heat sensitive

(Zeng et al., 1993)

embryonic/larval salivary gland | embryonic stage

(Andrew et al., 1994)

embryonic/larval salivary gland | embryonic stage | heat sensitive

(Zeng et al., 1993)

embryonic head | heat sensitive

(Zeng et al., 1993)

embryonic primordium of adult salivary gland

(Jullien et al., 1997)

eye | heat sensitive

(Zeng et al., 1993)

larval mesothoracic segment | heat sensitive

(Zeng et al., 1993)

larval metathoracic segment | heat sensitive

(Zeng et al., 1993)

mesothoracic ventral denticle belt | heat sensitive

(Zeng et al., 1993)

metathoracic ventral denticle belt | heat sensitive

(Zeng et al., 1993)

T1 beard | ectopic | heat sensitive

(Zeng et al., 1993)

Detailed Description

Statement

Reference

Embryos expressing Scr^hs.PZ develop supernumerary salivary glands in parasegments PS0 and PS1.

(Jullien et al., 1997)

Heat shock induces the production of ectopic salivary glands. Frequently the cells fuse with the normal salivary glands. Expression in the Antp P1 domain leads to ectopic salivary gland formation only when tsh is missing.

(Andrew et al., 1994)

In combination with Scr^hs.PG, tsh^hs.PdZ causes more extreme prothoracic transformations in procephalon and maxillary segment than tsh^hs.PdZ alone.

(de Zulueta et al., 1994)

Heat shock causes failure of head involution, ectopic beards in T2 and T3 and thickening of T2 and T3 denticle bands. Ectopic salivary gland is induced. Adult head shows thickened aristae and reduction of eye size.

(Zeng et al., 1993)

tsh expression is unchanged in heat shocked embryos in comparison to wild type.

(Roder et al., 1992)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Other

Statement

Reference

Scr^hs.PZ, tsh⁸ has embryonic primordium of adult salivary gland phenotype

(Jullien et al., 1997)

Abd-B^iab8-D16, Scr^hs.PZ has parasegment 1 phenotype

(Andrew et al., 1994)

Abd-B^iab8-D16, Scr^hs.PZ has embryonic/larval salivary gland | embryonic stage phenotype

(Andrew et al., 1994)

Abd-B^iab8-D16, Scr^hs.PZ has mandibular segment phenotype

(Andrew et al., 1994)

Abd-B^iab8-D16, Scr^hs.PZ has parasegment 14 phenotype

(Andrew et al., 1994)

Scr^hs.PZ, Ubx^6.28 has T1 beard & abdominal segment 1 phenotype

(Andrew et al., 1994)

Additional Comments

Genetic Interactions

Statement

Reference

tsh⁸ embryos expressing Scr^hs.PZ develop supernumerary salivary glands in parasegments PS0-PS1 and in PS3-PS13.

(Jullien et al., 1997)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Zeng.

(Andrew et al., 1994, Graba et al., 1994)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Scr^hs.PZ

Name Synonyms

heat shock construct of Zeng

(Zeng et al., 1993)

Secondary FlyBase IDs

References (13)

Report Sections

Open Close