FlyBase Allele Report: Dmel\eya[E12]

General Information

Symbol

Dmel\eya^E12

Species

D. melanogaster

Name

FlyBase ID

FBal0030765

Feature type

allele

Associated gene

Dmel\eya

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Bui et al., 2000, Bonini et al., 1998, Bonini et al., 1993)

Progenitor genotype

Cytology

Description

Amino acid replacement: W646term.

(Bui et al., 2000)

Nucleotide substitution: G2332A.

(Bui et al., 2000)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2L:6,528,432..6,528,432 [-]

Nucleotide change:

G6528432A

Reported nucleotide change:

G2332A

Amino acid change:

W652term | eya-PA; W646term | eya-PB; W562term | eya-PC

Reported amino acid change:

W646term

(Bui et al., 2000)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Bonini et al., 1998)

lethal - all die during embryonic stage (with eya^E(P)10)

(Bui et al., 2000)

partially lethal | recessive

(Leiserson et al., 1998)

some die during embryonic stage (with eya^E(P)10)

(Bui et al., 2000)

visible (with eya¹)

(Bui et al., 2000)

visible | recessive

(Bonini et al., 1998, Leiserson et al., 1998, Bonini et al., 1993)

Phenotype Manifest In

eye

(Bonini et al., 1998, Leiserson et al., 1998)

eye (with eya¹)

(Bui et al., 2000)

Detailed Description

Statement

Reference

eya¹/eya^E12 flies are eyeless or have eyes reduced to less than 1/4 normal size. More than 50% of eya^E12/eya^E(P)10 animals die as embryos.

(Bui et al., 2000)

eya^E12/eya¹ flies may be eyeless, or may have eyes that are less than 1/4 normal size. eya^E12/eya³ flies are eyeless.

(Bonini et al., 1998)

50% to less than 100% of eya^E12/Df(2L)eya¹⁰ embryos hatch. Less than 50% of eya^E12/eya^E3 animals survive to adulthood. Adults have eyes which are less than 1/2 normal size. eya^E12/eya⁴ flies are eyeless.

(Leiserson et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially complements

eya¹

(Bonini et al., 1993)

Comments

Fails to complement eye phenotype of eya¹.

(Bonini et al., 1993)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

cli^eya-E12

eya^E12

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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