FlyBase Allele Report: Dmel\cpo[l2]

General Information

Symbol

Dmel\cpo^l2

Species

D. melanogaster

Name

FlyBase ID

FBal0030938

Feature type

allele

Associated gene

Dmel\cpo

Associated Insertion(s)

P{lacZ}cpo^l2

Carried in Construct

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Bellen et al., 1992)

Progenitor genotype

Associated Insertion(s)

P{lacZ}cpo^l2

Cytology

Description

Insertion in an intron of cpo, 38bp upstream of the transcription start site (insertion site is between nucleotides 12297 and 12298 of scaffold AE003720, release 3).

(Glasscock and Tanouye, 2005)

Insertion of 10kb P{lacZ} at position 0 of cpo walk.

(Bellen et al., 1992)

Insertion of P element at cytological position 90D, into an intron of cpo.

(Bellen et al., 1992)

Allele components

Component

Use(s)

Inserted element

P{lacZ}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

neuron of chordotonal organ

(Bellen et al., 1992)

Additional Information

Statement

Reference

cpo protein is lacking in all embryonic cells that normally express it except the chordotonal neurons.

(Bellen et al., 1992)

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal behavior (with cpo¹)

(Bellen et al., 1992)

abnormal behavior (with cpo²)

(Bellen et al., 1992)

abnormal flight (with cpo¹)

(Bellen et al., 1992)

abnormal flight (with cpo²)

(Bellen et al., 1992)

abnormal locomotor behavior | adult stage (with cpo¹)

(Bellen et al., 1992)

abnormal locomotor behavior | adult stage (with cpo²)

(Bellen et al., 1992)

abnormal phototaxis (with cpo¹)

(Bellen et al., 1992)

abnormal phototaxis (with cpo²)

(Bellen et al., 1992)

bang sensitive (with cpo¹)

(Glasscock and Tanouye, 2005)

bang sensitive (with cpo²)

(Glasscock and Tanouye, 2005)

lethal | recessive

(Glasscock and Tanouye, 2005, Bellen et al., 1992, Bellen et al., 1992)

viable (with cpo¹)

(Glasscock and Tanouye, 2005)

viable (with cpo²)

(Glasscock and Tanouye, 2005)

Phenotype Manifest In

Detailed Description

Statement

Reference

Behavioural defects in phototaxis, geotaxis, flight response and recovery from ether anaesthesia are seen when transheterozygous with either cpo¹ or cpo².

(Bellen et al., 1992)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

cpo[+]/cpo^l2 is an enhancer of bang sensitive | dominant phenotype of jus^iso7.8

(Glasscock and Tanouye, 2005)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

cpo^v3

(Bellen et al., 1992)

Fails to complement

cpo^EG1

(Glasscock and Tanouye, 2005)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Allelic series: cpo^EG1 >= cpo^l2 > cpo¹ >= cpo².

(Glasscock and Tanouye, 2005)

Fails to complement cpo¹ and cpo².

(Bellen et al., 1992)

Allelic series of cpo alleles: cpo^lΔcp11 > cpo^l1 = cpo^l2 = cpo^l3 = cpo^l4 = cpo^l5 = cpo^l6 = cpo^j4A1 = cpo^l8 > cpo^l9 > cpo^lΔcp12 > cpo¹ = cpo².

(Bellen et al., 1992)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

8B7

cpo^l2

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

Open Close