FlyBase Allele Report: Dmel\cpo[1]

General Information

Symbol

Dmel\cpo¹

Species

D. melanogaster

Name

FlyBase ID

FBal0030933

Feature type

allele

Associated gene

Dmel\cpo

Associated Insertion(s)

P{lArB}cpo¹

Carried in Construct

Also Known As

cpo^cp1

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Bellen et al., 1992)

Mutagen

P-element activity

(Bellen et al., 1992)

Progenitor genotype

Associated Insertion(s)

P{lArB}cpo¹

Cytology

Description

Insertion in an intron of cpo, 38bp upstream of the transcription start site (insertion site is between nucleotides 12297 and 12298 of scaffold AE003720, release 3).

(Glasscock and Tanouye, 2005)

Insertion of 17kb P{lacZ} at position 0 of cpo walk, between putative zeste-binding sites and putative transcription start site.

(Bellen et al., 1992)

Insertion of P element at cytological position 90D, into an intron of cpo.

(Bellen et al., 1992)

Allele components

Component

Use(s)

Inserted element

P{lArB}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal behavior

(Bellen et al., 1992)

abnormal behavior (with cpo²)

(Bellen et al., 1992)

abnormal behavior (with cpo^EG1)

(Glasscock and Tanouye, 2005)

abnormal behavior (with cpo^l1)

(Bellen et al., 1992)

abnormal behavior (with cpo^l2)

(Bellen et al., 1992)

abnormal behavior | recessive

(Bellen et al., 1992)

abnormal flight

(Bellen et al., 1992)

abnormal flight (with cpo^EG1)

(Glasscock and Tanouye, 2005)

abnormal flight (with cpo^l1)

(Bellen et al., 1992)

abnormal flight (with cpo^l2)

(Bellen et al., 1992)

abnormal locomotor behavior | adult stage

(Bellen et al., 1992)

abnormal locomotor behavior | adult stage (with cpo^EG1)

(Glasscock and Tanouye, 2005)

abnormal locomotor behavior | adult stage (with cpo^l1)

(Bellen et al., 1992)

abnormal locomotor behavior | adult stage (with cpo^l2)

(Bellen et al., 1992)

abnormal mating (with cpo^EG1)

(Glasscock and Tanouye, 2005)

abnormal neurophysiology (with cpo^EG1)

(Glasscock and Tanouye, 2005)

abnormal phototaxis

(Bellen et al., 1992)

abnormal phototaxis (with cpo²)

(Bellen et al., 1992)

abnormal phototaxis (with cpo^EG1)

(Glasscock and Tanouye, 2005)

abnormal phototaxis (with cpo^l1)

(Bellen et al., 1992)

abnormal phototaxis (with cpo^l2)

(Bellen et al., 1992)

bang sensitive (with cpo²)

(Glasscock and Tanouye, 2005)

bang sensitive (with cpo^EG1)

(Glasscock and Tanouye, 2005)

bang sensitive (with cpo^l2)

(Glasscock and Tanouye, 2005)

decreased rate of movement (with cpo^EG1)

(Glasscock and Tanouye, 2005)

lethal | recessive

(Glasscock and Tanouye, 2005)

viable

(Bellen et al., 1992)

viable (with cpo²)

(Glasscock and Tanouye, 2005)

viable (with cpo^EG1)

(Glasscock and Tanouye, 2005)

viable (with cpo^l2)

(Glasscock and Tanouye, 2005)

Phenotype Manifest In

Detailed Description

Statement

Reference

cpo^EG1/cpo¹ flies have behavioural abnormalities in phototaxis, geotaxis, flight and recovery from ether. The flies are sluggish and show defects in mating vigour. cpo^EG1/cpo¹ and flies are more sensitive to seizures induced by a high frequency stimulus than wild-type flies; the mean seizure threshold is reduced compared to wild-type flies, to 11.1 +/- 3.7 V. The recovery period following seizure for cpo^EG1/cpo¹ flies is 83.2 +/- 23.8 seconds, which is considerably longer than the recovery period of wild-type flies. The firing threshold of the giant fiber in cpo¹/+ and cpo^EG1/cpo¹ flies is not significantly different from wild type. The giant fiber-tergotrochanteral muscle (GF-TTM) response is abnormal cpo^EG1/cpo¹ flies; the wild-type short latency response is replaced by a longer latency response that cannot follow even moderate frequencies of stimulation. However, in response to direct electrical stimulation, the cpo^EG1/cpo¹ TTM is similar to wild type in latency and following frequency. The giant fiber-dorsal longitudinal muscle (GF-DLM) response in cpo^EG1/cpo¹ animals is normal in latency but impaired in following frequency. In response to direct electrical stimulation, the cpo^EG1/cpo¹ DLM is similar to wild type in latency and following frequency.

(Glasscock and Tanouye, 2005)

Behavioural defects in the adult.

(Bellen et al., 1992)

Behavioural defects in phototaxis, geotaxis, flight response and recovery from ether anaesthesia are seen in homozygotes and in transheterozygotes with either cpo^l1 or cpo^l2. Behavioural defects in phototaxis and recovery from ether anaesthesia are seen in transheterozygotes with cpo².

(Bellen et al., 1992)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

cpo[+]/cpo¹ is an enhancer of bang sensitive | dominant phenotype of jus^iso7.8

(Glasscock and Tanouye, 2005)

Other