FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\disco1656
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General Information
Symbol
Dmel\disco1656
Species
D. melanogaster
Name
FlyBase ID
FBal0031021
Feature type
allele
Associated gene
Dmel\disco
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Lee et al., 1999)
Mutagen
ethyl methanesulfonate
(Heilig et al., 1991)
Progenitor genotype
Cytology
Description

Amino acid replacement: C94Y. A missense alteration of the first Cys residue in the first zinc finger to a Tyr.

(Lee et al., 1999)

Single base change resulting in a missense mutation. Amino acid replacement: C??.

(Heilig et al., 1991)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:16,212,998..16,212,998 [-]
Nucleotide change:

G16212998A

Reported nucleotide change:

G?A

Amino acid change:

C94Y | disco-PA; C94Y | disco-PB

Reported amino acid change:

C94Y

(Heilig et al., 1991)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous mutants display ~97% lethality throughout larval and pupal development.

      ~12% of disco1/disco1656 pupae and adult escapers show antenna phenotypes, characterized by the disruption and deletion of the arista and the partial truncation of antennal segment 3.

      ~5% of disco1/disco1656 pupae show leg phenotypes, mostly characterized by the shrinkage of the femur and tibia, and the deletion of the distal tarsus and claw.

      (Dey et al., 2009)

      Loss of disco activity in the disco1656 allele has no apparent effect on the cellular identity or differentiation of the majority of the cells in the optic lobe primordium.

      (Lee et al., 1999)

      Flies are arrhythmic in constant darkness. Locomotor activity of flies in light-dark cycles demonstrates they manifest a morning activity peak in anticipation of lights-on and a larger evening activity peak anticipating lights-off. These activity profiles suggest the presence of an active pacemaker. This is confirmed by the shift in the phase of the evening activity peak in the presence of pers (shifted to an earlier time) and perL1 (shifted to a later time).

      (Hardin et al., 1992)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      disco1656
      (Dey et al., 2009)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)