FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ebo1041
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General Information
Symbol
Dmel\ebo1041
Species
D. melanogaster
Name
FlyBase ID
FBal0031194
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
ebo4
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
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    Variant Molecular Consequences
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
    Expression Data
    Reporter Expression
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    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
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    Modifiers Based on Experimental Evidence ( 0 )
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    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    ebo678 mutant flies exhibit a normal external appearance. However, the ellipsoid body (EB) is split in two in 50% of ebo678 mutant flies. The fan-shaped body (FB) also appears to be vertically divided in the middle.

    Tethered ebo678 mutants fly readily and for extended period of time which may be longer than in wild-type. Average torque traces and optomotor response appear as in wild-type. Torque spike rate is only slightly, and not significantly, reduced in these mutants. The amplitude of the small torque oscillations in between spikes is also reduced. The size and shape of torque spikes in these mutants are not noticeably abnormal. eboKS263 mutants exhibit normal optomotor response dynamics.

    In a closed-loop with a single stripe (flight simulator), ebo1041 mutants behave close to normal. For over 85% of their flight time they keep the stripe in a frontal (+/- 15[o]) position.

    Mutants have impaired visual pattern memory.

    Show normal ability to develop ethanol tolerance.

    Mushroom body defects are similar to ebo678. The ellipsoid body is open ventrally, flattened and occasionally divided. The fan-shaped body is split in many flies.

    Females display increased ovulation and low receptivity after Acp70A injection.

    Flight behaviour shows reduced amplitude in the small random oscillations of the torque trace (yaw torque activity). The frequency of torque spikes is significantly reduced (torque spike frequency). Flies behave close to normal in a single stripe flight simulator (on-target fixation). Gyandromorphs demonstrate the behavioural phenotypes yaw torque activity and torque spike frequency are all highly correlated with the phenotype of the ellipsoid body.

    Ellipsoid body usually open ventrally (kidney shaped or horizontal bar shaped) and may dissociate. Phenotype of ebo1041 stronger than that of ebo678, which in turn is stronger than eboKS263.

    External Data
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    Complementation and Rescue Data
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    Mutant
    Wild-type
    Stocks (1)
    Notes on Origin
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    Comments
    Comments

    The following alleles can be ranked, with respect to the severity of the defects observed in flight control behavior, from weak to strong, as follows: ebo[1041] > ebo[KS263] > ebo[678].

    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (3)
    Reported As
    Name Synonyms
    Secondary FlyBase IDs
      References (9)