FlyBase Allele Report: Dmel\fzy[4]

General Information

Symbol

Dmel\fzy⁴

Species

D. melanogaster

Name

FlyBase ID

FBal0031373

Feature type

allele

Associated gene

Dmel\fzy

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

heat sensitive hypomorphic allele - genetic evidence

Mutagen

Nature of the Allele

Allele class

heat sensitive hypomorphic allele - genetic evidence

(Dawson et al., 1993)

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | larval stage | somatic clone

(Kuang et al., 2014)

abnormal size | larval stage | somatic clone

(Kuang et al., 2014)

lethal | recessive | heat sensitive

(Dawson et al., 1993)

Phenotype Manifest In

embryonic/larval optic lobe | larval stage | somatic clone

(Kuang et al., 2014)

neuroblast | larval stage | somatic clone

(Kuang et al., 2014)

Detailed Description

Statement

Reference

55% of fzy⁴ mutant clones generated in the brain during the larval stages do not contain neuroblasts, compared to <10% in controls.

Unlike in wild type, fzy⁴ mutant neuroepithelial cell clones in the larval optic lobe fail to proliferate.

Unlike in wild type, almost all fzy⁴ mutant neuroblast clones in the larval brain fail to proliferate.

fzy⁵⁰³²/fzy⁴ mutant neuroblasts maintain a single nucleus and cell diameters are similar to wild type.

(Kuang et al., 2014)

At 25^oC, embryonic lethal, ventral epidermis absent, CNS degenerate, PNS absent. At 18^oC, embryonic lethal, holes in ventral epidermis, CNS degenerate.

(Dawson et al., 1993)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

fzy⁴ has abnormal size | somatic clone | larval stage phenotype, suppressible by Scer\GAL4^elav.PU/Mmus\Cdc20^UAS.cKa

(Kuang et al., 2014)

fzy⁴ has abnormal size | somatic clone | larval stage phenotype, suppressible by Scer\GAL4^elav.PU/Mmus\Cdc20^mut.UAS

(Kuang et al., 2014)

NOT Suppressor of

Statement

Reference

fzy[+]/fzy⁴ is a non-suppressor of increased cell death phenotype of shtd¹

(Tanaka-Matakatsu et al., 2007)

Phenotype Manifest In

Suppressed by

Statement

Reference

fzy⁴ has embryonic/larval optic lobe | somatic clone | larval stage phenotype, suppressible by Scer\GAL4^elav.PU/Mmus\Cdc20^UAS.cKa

(Kuang et al., 2014)

fzy⁴ has neuroblast | somatic clone | larval stage phenotype, suppressible by Scer\GAL4^elav.PU/Mmus\Cdc20^UAS.cKa

(Kuang et al., 2014)

fzy⁴ has embryonic/larval optic lobe | somatic clone | larval stage phenotype, suppressible by Scer\GAL4^elav.PU/Mmus\Cdc20^mut.UAS

(Kuang et al., 2014)

fzy⁴ has neuroblast | somatic clone | larval stage phenotype, suppressible by Scer\GAL4^elav.PU/Mmus\Cdc20^mut.UAS

(Kuang et al., 2014)

NOT Suppressor of

Statement

Reference

fzy[+]/fzy⁴ is a non-suppressor of eye phenotype of shtd¹

(Tanaka-Matakatsu et al., 2007)

fzy[+]/fzy⁴ is a non-suppressor of ommatidium phenotype of shtd¹

(Tanaka-Matakatsu et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Expression of Mmus\Cdc20^Scer\UAS.cKa under the control of Scer\GAL4^elav.PU rescues the proliferation defects seen in fzy⁴ mutant neuroepithelial cell clones in the larval optic lobe.

Expression of Mmus\Cdc20^Scer\UAS.cKa under the control of Scer\GAL4^elav.PU partially rescues the proliferation defects seen in fzy⁴ mutant neuroblast clones in the larval brain.

Expression of Mmus\Cdc20^mut.Scer\UAS under the control of Scer\GAL4^elav.PU rescues the proliferation defects seen in fzy⁴ mutant neuroepithelial cell clones in the larval optic lobe.

Expression of Mmus\Cdc20^mut.Scer\UAS under the control of Scer\GAL4^elav.PU partially rescues the proliferation defects seen in fzy⁴ mutant neuroblast clones in the larval brain.

(Kuang et al., 2014)

Complementation and Rescue Data

Rescued by

fzy⁴ is rescued by Scer\GAL4^elav.PU/fzy^UAS.cKa

(Kuang et al., 2014)

Partially rescued by

fzy⁴ is partially rescued by fzy^UAS.5032/Scer\GAL4^elav.PU

(Kuang et al., 2014)

Comments

Expression of fzy^Scer\UAS.cKa under the control of Scer\GAL4^elav.PU rescues the proliferation defects seen in fzy⁴ mutant neuroepithelial cell clones in the larval optic lobe.

Expression of fzy^Scer\UAS.cKa under the control of Scer\GAL4^elav.PU rescues the proliferation defects seen in fzy⁴ mutant neuroblast clones in the larval brain.

Expression of fzy^{Scer\UAS.5032} under the control of Scer\GAL4^elav.PU rescues the proliferation defects seen in fzy⁴ mutant neuroepithelial cell clones in the larval optic lobe.

Expression of fzy^{Scer\UAS.5032} under the control of Scer\GAL4^elav.PU fails to rescue the proliferation defects seen in fzy⁴ mutant neuroblast clones in the larval brain.

(Kuang et al., 2014)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

P. Simpson.

(Roote, 1995.5.4)

Comments

Phenotypic data included in FBrf0051973.

(Roote, 1995.5.4)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

AB155

IB115

(Roote, 1995.5.4)

fzy⁴

(Kuang et al., 2014, Tanaka-Matakatsu et al., 2007)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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