FlyBase Allele Report: Dmel\aos[A254Δ5]

General Information

Symbol

Dmel\aos^A254Δ5

Species

D. melanogaster

Name

FlyBase ID

FBal0031393

Feature type

allele

Associated gene

Dmel\aos

Associated Insertion(s)

P{lArB}aos^A254Δ5

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Kretzschmar et al., 1992)

Mutagen

Delta2-3 transposase

(Brunner et al., 1993, Kretzschmar et al., 1992)

Progenitor genotype

P{lArB}aos^A254

(Brunner et al., 1993)

aos^A254

(Kretzschmar et al., 1992)

Associated Insertion(s)

P{lArB}aos^A254Δ5

Cytology

Description

Imprecise excision of P{lArB}argos^A254.

(Brunner et al., 1993)

Small deletion removing part of the argos leader sequence leaving the open reading frame intact.

(Kretzschmar et al., 1992)

Allele components

Component

Use(s)

Inserted element

P{lArB}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal visual behavior

(Brunner et al., 1993)

viable

(Brunner et al., 1994, Kretzschmar et al., 1992)

Phenotype Manifest In

eye photoreceptor cell

(Kretzschmar et al., 1992)

lamina

(Kretzschmar et al., 1992)

lens

(Kretzschmar et al., 1992)

lobula

(Kretzschmar et al., 1992)

medulla

(Kretzschmar et al., 1992)

ommatidium

(Brunner et al., 1993)

optic nerve

(Brunner et al., 1993)

rhabdomere

(Kretzschmar et al., 1992)

Detailed Description

Statement

Reference

Homozygous viable. In the posterior region of the eye the lenses of many ommatidia fuse to build one giant lens. Each ommatidia has an increased number of cone cells, 7-10 compared to 4 in wild type eyes. Axons that grow through the optic stalk into the larval brain stall on entry into the larval brain hemisphere and show an aberrant projection pattern.

(Brunner et al., 1993)

Exhibit argos rough eye phenotype (due to additional photoreceptors) and fused lens phenotype in the posterior eye. Photoreceptor axons project through the optic stalk into the lamina presumptive area but fail to penetrate into deeper layers of the developing optic lobe. The optic lobe shows variable degrees of disorganisation, defects can be detected in the lamina, medulla and lobula complex.

(Kretzschmar et al., 1992)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Mutation has no effect on rho^hs.sev rough eye phenotype.

(Freeman, 1994)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

aos^A254Δ5

argos^A254Δ5

argos^gil5

(Freeman, 1994)

gil^A254Δ5

gil^Δ5

(Brunner et al., 1994, Brunner et al., 1993)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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