FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\higP1
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General Information
Symbol
Dmel\higP1
Species
D. melanogaster
Name
FlyBase ID
FBal0031491
Feature type
allele
Associated gene
Dmel\hig
Associated Insertion(s)
P{FZ}higP1
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Hoshino et al., 1993)
Progenitor genotype
Associated Insertion(s)
P{FZ}higP1
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{FZ}
Encoded product / tool
lacZ
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      No Assay Recorded
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      embryonic stage -- adult stage
      adult optic lobe
      (Hoshino et al., 1993)
      adult stage
      adult brain | restricted
      (Hoshino et al., 1993)
      distribution deduced from reporter
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      embryonic stage -- adult stage
      adult ventral nerve cord | restricted
      (Hoshino et al., 1993)
      central nervous system
      (Hoshino et al., 1993)
      larval stage
      larval brain | restricted
      (Hoshino et al., 1993)
      Additional Information
      Statement
      Reference

      The CNS is the only site of significant staining in embryos, larvae, pupae and adults. In adults, optic lobe staining is strong. Weaker staining is observed in the central brain and ventral ganglion.

      (Hoshino et al., 1993)

      The level of hig transcripts is reduced to 15% of the wild type level in adult heads.

      (Sanchez-Herrero and Akam, 1989)
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Larval locomotor activity uncoordinated. Adult homozygotes show very reduced activity and rarely fly, but respond vigorously to strong light or chemical odour. Individuals die soon after eclosion.

      (Hoshino et al., 1993)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      higP1 is partially rescued by higD12.hs

      (Hoshino et al., 1993)
      Comments

      Some lines of higD12.hs were found to rescue the higP1 mutation to various extents in terms of locomotion and longevity at the adult stages at 25oC.

      (Hoshino et al., 1993)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Mobilisation of the P{FZ} insertion demonstrates it to be the cause of the mutant phenotype, a wild type revertant was isolated.

      (Hoshino et al., 1993)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      higP1
      Name Synonyms
      Secondary FlyBase IDs
        References (2)