FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\hkb1
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General Information
Symbol
Dmel\hkb1
Species
D. melanogaster
Name
FlyBase ID
FBal0031493
Feature type
allele
Associated gene
Dmel\hkb
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Weigel et al., 1990)
Mutagen
ethyl methanesulfonate
(Weigel et al., 1990)
Progenitor genotype
Cytology
Description

Small deletion within the coding region from position 303 to 616.

(Bronner et al., 1994)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3R:4,345,885..4,346,199 [-]
Comment:

Deletion of bases 303-616 of the cDNA sequence in FBrf0072695.

(Bronner et al., 1994)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutant embryos show a large reduction in the number of denticles, and those remaining are reduced in pigmentation. The mouthparts and posterior spiracles are reduced in pigmentation and structural defects are seen in the mouthparts. The central nervous system shows large disruptions which can extend over several segments. The NB 7-3 neuroblast has normal morphology in mutant embryos.

      (Lundell et al., 1996)

      Neuroblast formation is unaffected, though neuroblast NB4-2 is mutant as assayed by eve expression. Overall CNS scaffold structure is normal, but with occasional thin connectives and slightly fused commissures in some hemisegments. RP2 neuron axon shows variable ipsilateral projection. Shows possible target recognition defects and delayed/defective synapse formation. Motoneurons from NB4-2 have axon pathfinding defects.

      (Chu-LaGraff et al., 1995)

      Failure of head involution. Absence of anterior midgut. Reduction in posterior midgut.

      (Weigel et al., 1990)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      hkb2/hkb1 is rescued by hkbtBa

      (Bronner et al., 1994)
      Comments

      hkb1/hkb2 heterozygous embryos can be rescued by the hkbtBa construct, embryonic gut, ventral furrow and head involution is normal, labral derivatives are abnormal. 4% survive to adulthood, these flies cannot fly and fail to respond to optic stimuli.

      (Bronner et al., 1994)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      G.J. Anderson and K.V. Anderson.

      (Weigel et al., 1990)
      Comments
      Comments

      Isolated in a screen for mutations affecting head development. hkb2 exhibits a more extreme phenotype than hkb1.

      (Weigel et al., 1990)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      hkb1
      (Lundell et al., 1996)
      Name Synonyms
      Secondary FlyBase IDs
        References (7)