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General Information
Symbol
Dmel\l(2)gd1d3
Species
D. melanogaster
Name
FlyBase ID
FBal0031804
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Hyperplastic imaginal disc overgrowth, affecting all discs. Discs implanted into wild type hosts for metamorphosis overgrow and differentiate abnormal imaginal structures. l(2)gd11/l(2)gd1d3 mutant larvae grow at a normal rate until end of feeding period of last larval instar, when growth slows and then stops: they eventually reach double the weight of wild type pupariating larvae.

Chimeras with l(2)gd1d3/l(2)gd11 germ cells produce mostly abnormal eggs; half of the eggs are flaccid and slightly reduced in size. The dorsal appendages are often fused at their site of origin and are wilder than wild-type. Some eggs do not collapse and develop into embryos, although the dorsal appendages are still slightly abnormal. Most of the developing larvae die before hatching, some appear normal, but others have severe head defects and abnormal ventral setal belts. Eggs derived from homozygous germ-line clones have fused and reduced dorsal appendages.

Hyperplastic growth. Imaginal discs show normal gap-junctional communication.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Pole cell transplantation and germ-line clonal analysis indicates that the l(2)gd1 product is required for normal germ-line development and/or subsequent embryogenesis. Analysis of follicle cell mosaics indicates that l(2)gd1 is not required for follicle cell functions.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
l(2)gd1d3
Name Synonyms
Secondary FlyBase IDs
    References (3)