Hyperplastic imaginal disc overgrowth, affecting all discs. Discs implanted into wild type hosts for metamorphosis overgrow and differentiate abnormal imaginal structures. l(2)gd11/l(2)gd1d3 mutant larvae grow at a normal rate until end of feeding period of last larval instar, when growth slows and then stops: they eventually reach double the weight of wild type pupariating larvae.
Chimeras with l(2)gd1d3/l(2)gd11 germ cells produce mostly abnormal eggs; half of the eggs are flaccid and slightly reduced in size. The dorsal appendages are often fused at their site of origin and are wilder than wild-type. Some eggs do not collapse and develop into embryos, although the dorsal appendages are still slightly abnormal. Most of the developing larvae die before hatching, some appear normal, but others have severe head defects and abnormal ventral setal belts. Eggs derived from homozygous germ-line clones have fused and reduced dorsal appendages.
Hyperplastic growth. Imaginal discs show normal gap-junctional communication.
Pole cell transplantation and germ-line clonal analysis indicates that the l(2)gd1 product is required for normal germ-line development and/or subsequent embryogenesis. Analysis of follicle cell mosaics indicates that l(2)gd1 is not required for follicle cell functions.