FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Dlatmuc-1
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General Information
Symbol
Dmel\Dlatmuc-1
Species
D. melanogaster
Name
FlyBase ID
FBal0032195
Feature type
allele
Associated gene
Dmel\Dlat
Associated Insertion(s)
P{lacW}Dlatmuc-1
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Phillis et al., 1993)
Progenitor genotype
Associated Insertion(s)
P{lacW}Dlatmuc-1
Cytology
Description

Mobilization of P{lacW}.

(Murphy and Phillis, 1993)
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Abnormal grooming behaviour, front and hind legs do not touch the midline and therefore cannot remove dust particles. Axonal projections of the sensory neurons innervating the ASC and PSC macrochaetes lack the axonal branch contralateral to the cell body.

      (Murphy and Phillis, 1993)

      Flies remain dusty in a dust removal assay. Normal leg sweeping but leg rubbing is defective. Though the pairs of legs move back and forth in rubbing movements flies fail to get them together on the midline, so they rub back and forth in parallel, rather than touching. Movements are shaky and the flies frequently fall over while they are grooming. Flies walk on a flat surface and can fly. High levels of responsiveness in a single bristle scratch reflex test.

      (Phillis et al., 1993)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Transposase-induced excision of the P insertion is accompanied by phenotypic reversion of the mutant phenotype.

      (Phillis et al., 1993)

      Excision of the P-element reverts the behavioural and axonal phenotypes caused by the insert.

      (Murphy and Phillis, 1993)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Dlat1
      Dlatmuc-1
      muc1
      Name Synonyms
      Secondary FlyBase IDs
        References (3)