FlyBase Allele Report: Dmel\mys[4A.hs]

General Information

Symbol

Dmel\mys^4A.hs

Species

D. melanogaster

Name

FlyBase ID

FBal0032210

Feature type

allele

Associated gene

Dmel\mys

Associated Insertion(s)

Carried in Construct

P{hsp.mys4A}

Key Links

Transgenic product class

cDNA

(Zusman et al., 1993)

wild_type

(Zusman et al., 1993)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Zusman et al., 1993)

wild_type

(Zusman et al., 1993)

Mutagen

in vitro construct

(Bunch et al., 1998, Graner et al., 1998, Zusman et al., 1993)

Progenitor genotype

Carried in construct

P{hsp.mys4A}

Cytology

Description

An Hsp70 promoter drives expression of a cDNA encoding the mys 4A splice variant.

(Zusman et al., 1993)

Allele components

Component

Use(s)

Regulatory region(s)

Hsp70

Encoded product / tool

mys

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Schneider line 2 cells coexpressing if^C.hs and mys^4A.hs which have been treated with protease to clear surface proteins and ECM show spreading on a substrate coated with a protein containing the Tig RGD. Schneider line 2 cells coexpressing if^C.hs and mys^4A.hs also show spreading if they are not pretreated with protease and are grown in normal growth medium with serum on an uncoated substrate.

(Jannuzi et al., 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescues

mys^4A.hs partially rescues mys¹¹

(Zusman et al., 1993)

Comments

Shift up experiments show significant rescue of the wing blister and eye phenotypes of mys¹¹ clones.

(Zusman et al., 1993)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Carried in a plasmid, transfected into S2 cells and used in cell spreading assays.

(Bunch et al., 1998)

Carried in a plasmid, expressed in Schneider line 2 cells and used in cell spreading assays.

(Jannuzi et al., 2002, Graner et al., 1998)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

mys^4A.hs

β_PS4A

(Graner et al., 1998)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

Open Close