FlyBase Allele Report: Dmel\ninaA[E110V]

General Information

Symbol

Dmel\ninaA^E110V

Species

D. melanogaster

Name

FlyBase ID

FBal0032239

Feature type

allele

Associated gene

Dmel\ninaA

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Mendes et al., 2009)

Mutagen

ethyl methanesulfonate

(Ondek et al., 1992)

Progenitor genotype

Cytology

Description

Amino acid replacement: E110V.

(Ondek et al., 1992)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2L:877,690..877,690 [+]

Nucleotide change:

A877690T

Amino acid change:

E110V | ninaA-PA

Reported amino acid change:

E110V

Comment:

Site of nucleic acid substitution inferred by FlyBase based on reported amino acid change

(Ondek et al., 1992)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell death

(Mendes et al., 2009)

visible | recessive

(Ondek et al., 1992)

Phenotype Manifest In

ommatidium

(Mendes et al., 2009)

photoreceptor neuron

(Mendes et al., 2009)

Detailed Description

Statement

Reference

Sixty-day old ninaA^E110V homozygous mutant retina display defects in the ommatidia trapezoidal arrangement and occasional photoreceptor cell loss. Conversely, heterozygous ninaA^E110V mutant retinas (with moderate ER stress) remain intact, showing normal morphology despite displaying hallmarks of ER stress and 'unfolded protein response' activation.

(Mendes et al., 2009)

Deep pseudopupil score of 5.

(Ondek et al., 1992)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

ninaA[+]/ninaA^E110V, Scer\GAL4^ninaE.PT is a non-enhancer of decreased cell death phenotype of BacA\p35^GMR.PH, Scer\GAL4^ninaE.PT, p53^UAS.cJa

(Mendes et al., 2009)

Suppressor of

Statement

Reference

ninaA[+]/ninaA^E110V is a suppressor of increased cell death phenotype of p53^UAS.cJa

(Mendes et al., 2009)

ninaA[+]/ninaA^E110V, Scer\GAL4^ninaE.PT is a suppressor of increased cell death phenotype of Dcp-1^UAS.cPa, Scer\GAL4^ninaE.PT

(Mendes et al., 2009)

ninaA[+]/ninaA^E110V is a suppressor of increased cell death phenotype of Apc^Q8

(Mendes et al., 2009)

ninaA^E110V is a suppressor of increased cell death phenotype of Apc^Q8

(Mendes et al., 2009)

ninaA[+], ninaA^E110V, Scer\GAL4^ninaE.PT is a suppressor of increased cell death phenotype of rpr^UAS.cZa

(Mendes et al., 2009)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

ninaA[+]/ninaA^E110V, Scer\GAL4^ninaE.PT is a non-enhancer of outer photoreceptor cell phenotype of BacA\p35^GMR.PH, Scer\GAL4^ninaE.PT, p53^UAS.cJa

(Mendes et al., 2009)

Suppressor of

Statement

Reference

ninaA[+]/ninaA^E110V is a suppressor of outer photoreceptor cell phenotype of p53^UAS.cJa

(Mendes et al., 2009)

ninaA[+]/ninaA^E110V, Scer\GAL4^ninaE.PT is a suppressor of outer photoreceptor cell phenotype of Dcp-1^UAS.cPa, Scer\GAL4^ninaE.PT

(Mendes et al., 2009)

ninaA[+]/ninaA^E110V is a suppressor of photoreceptor neuron phenotype of Apc^Q8

(Mendes et al., 2009)

ninaA^E110V is a suppressor of photoreceptor neuron phenotype of Apc^Q8

(Mendes et al., 2009)

ninaA[+], ninaA^E110V, Scer\GAL4^ninaE.PT is a suppressor of outer photoreceptor cell phenotype of rpr^UAS.cZa

(Mendes et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

Loss of one genomic copy of ninaA, using the amorphic allele ninaA^E110V, protects the outer photoreceptor cells from rpr^Scer\UAS.cZa-induced apoptosis. This anti-apoptotic effect is dose-dependent, as complete loss of ninaA leads to further protection.

Loss of one genomic copy of ninaA, using the amorphic allele ninaA^E110V, protects the outer photoreceptor cells from p53^Scer\UAS.cJa-induced apoptosis.

Loss of one genomic copy of ninaA, using the amorphic allele ninaA^E110V, protects the outer photoreceptor cells from Dcp-1^Scer\UAS.cPa-induced apoptosis.

A heterozygous or homozygous ninaA^E110V background is sufficient to induce a partial rescue of photoreceptor cells from Apc^Q8-induced loss.

(Mendes et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

ninaA^E110V

(Coelho et al., 2013, Fouillet et al., 2012, Mendes et al., 2009)

Name Synonyms

Secondary FlyBase IDs

References (4)

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