FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ord4
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General Information
Symbol
Dmel\ord4
Species
D. melanogaster
Name
FlyBase ID
FBal0032313
Feature type
allele
Associated gene
Dmel\ord
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Miyazaki and Orr-Weaver, 1992)
Progenitor genotype
Cytology
Description

Amino acid replacement: A424V.

(Bickel et al., 1996)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:23,272,203..23,272,203 [-]
Nucleotide change:

C23272203T

Amino acid change:

A424V | ord-PA; A424V | ord-PB

Reported amino acid change:

A424V

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Bickel et al., 1996)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      When ord4/ord10 female flies with normal X chromosomes are subjected to a 4-day aging regimen (after collection of virgin females and feeding with yeast paste overnight, the virgin females are kept for 4 days in the absence of males, which results in the majority of oocytes halting in developmental progression and aging within the female abdomen, as oviposition is suppressed), sex chromosome nondisjunction is not significantly greater in aged oocytes than in non-aged oocytes.

      Meiotic crossovers on the X chromosomes are substantially reduced in ord4/ord10 oocytes; the total map distance is reduced to 20% or less of the wild type value.

      When subjected to the aging regimen, FM7a/X ; ord4/ord10 aged oocytes show a significant increase in nondisjunction that lasted for 48 hours. Reductional nondisjunction events predominate in both aged and non-aged oocytes.

      When subjected to the aging regimen, Df(1)bb158/X ; ord4/ord10 females show age-dependent nondisjunction; sex chromosome nondisjunction is significantly greater in aged oocytes than in non-aged oocytes.

      When subjected to the aging regimen, In(1)dl-49/X ; ord4/ord10 females do not show age-dependent nondisjunction.

      Heterochromatin pairing between the FM7a chromosome and a normal X chromosome is significantly disrupted in ord4/ord10 oocytes.

      (Subramanian and Bickel, 2009)

      ord4/Df(2R)3-70 mothers do not exhibit a significant age dependant increase in meiotic non-disjunction.

      (Jeffreys et al., 2003)

      Females exhibit high levels of sex chromosome missegregation compared to males. Mutation exhibits negative complementation when in combination with ord1, ord2 or ord6 in males and females, protein activity is poisoned.

      (Bickel et al., 1997)

      Levels of chromosome missegregation in homozygous males and females is very low. Female levels increase only slightly when transheterozygous with Df(2R)3-70, but are significant when transheterozygous with ord1 or ord2. Male levels do not increase when transheterozygous with Df(2R)3-70 or ord2, but are significant when transheterozygous with ord1.

      (Bickel et al., 1996)

      Increased frequency of premature sister chromatid disjunction.

      (Miyazaki and Orr-Weaver, 1992)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      ord4/ord10 animals also carrying FM7a balancer an age dependant increase in meiotic non-disjunction is seen.

      (Jeffreys et al., 2003)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Weak allele.

      (Miyazaki and Orr-Weaver, 1992)

      ord1 and ord2 interact with ord4 to alter the female meiotic chromosome segregation phenotype but ord3, ord5 and ord6 do not. ord1 and ord6 interacts with ord4 to alter the male meiotic chromosome segregation phenotype, the remaining alleles do not.

      (Bickel et al., 1996)

      Moderate ord mutation.

      (Bickel et al., 1997)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      ord4
      (Subramanian and Bickel, 2009)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)