orientation disrupter
rapidly evolving gene - involved in meiotic cohesion, chromosome core maintenance and homologous recombination
Please see the JBrowse view of Dmel\ord for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.52
2.7 (northern blot)
479 (aa); 55 (kD predicted)
Interacts with Sce.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\ord using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Protein is found in the nuclei of developing spermatocytes. It is extrachromosomal in stage S1-S3 spermatocytes (corresponding to early to mid G2 phase) but then becomes associated with chromatin during mid to late G2 phase. The ord protein is initially distributed uniformly over the chromatin but then is detected primarily at the centromere from metaphase of meiosis I through metaphase of meiosis II.
JBrowse - Visual display of RNA-Seq signals
View Dmel\ord in JBrowse2-102
2-106.9
2-103.5
2-103.1--103.6
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
ord is required for the maintenance of meiotic sister cohesion in oocytes.
Negative complementation occurs between strong alleles (typically showing poisoning activity) and weak alleles (typically are poisoned), it is not allele-specific, suggesting that protein-protein interactions are necessary for wild-type ord function. C-terminal part of ord is required to elicit negative complementation effects.
Meiotic sister-chromatid cohesion is severely disrupted in flies lacking ord protein and the frequency of missegregation in genetic tests suggests sister chromatid cohesion may be completely abolished. C-terminal part of ord is required for both aspects of ord function. ord function is not essential for cohesion during somatic mitosis as only a slight decrease in viability is observed.
ord is necessary for chromosome segregation and can interact specifically with the centromere.
ord is essential for sister chromatid cohesion during meiosis.
ord is required to maintain sister-chromatid cohesion during meiosis in both males an females. Mutations result in defects in cohesion before the first division.
All alleles are fully viable, even in trans to a deficiency, therefore ord+ has no essential role in somatic mitosis, though a role in mitosis in the germ line is suggested.
Mutations at ord affect sister chromatid cohesion during meiosis I in both males and females.
