FB2026_02 , released June 18, 2026
Allele: Dmel\ord2
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General Information
Symbol
Dmel\ord2
Species
D. melanogaster
Name
FlyBase ID
FBal0032311
Feature type
allele
Associated gene
Dmel\ord
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Miyazaki and Orr-Weaver, 1992)
Progenitor genotype
Cytology
Description

Amino acid replacement: A381T.

(Bickel et al., 1996)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:23,272,386..23,272,386 [-]
Nucleotide change:

G23272386A

Amino acid change:

A381T | ord-PA; A381T | ord-PB

Reported amino acid change:

A381T

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Bickel et al., 1996)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Encoded protein is able to poison the activity of ord4 in females: negative complementation. Mutation exhibits negative complementation when in combination with ord8 and ord11 in males, missegregation is greater in ord8/ord2 and ord11/ord2 transheterozygotes than that in ord8 or ord11 hemizygotes.

      (Bickel et al., 1997)

      Transmission rate of Dp(1;f)J21A through females to progeny is 28%, ord mutation has no effect on transmission. Mutation has no effect on Dp(1;f)J21A transmission in males.

      (Cook et al., 1997)

      Level of chromosome missegregation in heterozygous females is 0.2%, levels significantly increase when transheterozygous with ord4. Also the frequency of X chromosome exchange of the transheterozygous is lower compared to ord4 homozygotes.

      (Bickel et al., 1996)

      Increased frequency of premature sister chromatid disjunction. 30% of egg chambers have abnormal numbers of nurse cell nuclei.

      (Miyazaki and Orr-Weaver, 1992)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      ord11

      (Bickel et al., 1997)

      ord8

      (Bickel et al., 1997)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Strong allele.

      (Miyazaki and Orr-Weaver, 1992)

      Strong ord mutation.

      (Bickel et al., 1997)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      ord2
      Name Synonyms
      Secondary FlyBase IDs
        References (5)