FB2026_02 , released June 18, 2026
Allele: Dmel\ord6
Open Close
General Information
Symbol
Dmel\ord6
Species
D. melanogaster
Name
FlyBase ID
FBal0032315
Feature type
allele
Associated gene
Dmel\ord
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Miyazaki and Orr-Weaver, 1992)
Progenitor genotype
Cytology
Description

Amino acid replacement: W294R.

(Bickel et al., 1996)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:23,272,774..23,272,774 [-]
Nucleotide change:

T23272774M

Amino acid change:

W294R | ord-PA; W294R | ord-PB

Reported amino acid change:

W294R

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Bickel et al., 1996)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Recovery of the ring X chromosome R(1)2 relative to a normal rod X chromosome during female meiosis is significantly lowered in ord6/ord10 (ratio of ring/rod=0.4 compared to 0.7 in wild-type) mutants.

      (Webber et al., 2004)

      Meiotic recombination is reduced but not absent. Females exhibit high levels of sex chromosome missegregation compared to males. Encoded protein is able to poison the activity of ord4 in males and females: negative complementation. Mutation exhibits negative complementation when in combination with ord8 and ord11 in females, missegregation is greater in ord8/ord6 and ord11/ord6 transheterozygotes than that in ord8 or ord11 hemizygotes.

      (Bickel et al., 1997)

      Level of chromosome missegregation in heterozygous males significantly increases when transheterozygous with ord4.

      (Bickel et al., 1996)

      Increased frequency of premature sister chromatid disjunction.

      (Miyazaki and Orr-Weaver, 1992)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      ord11

      (Bickel et al., 1997)

      ord8

      (Bickel et al., 1997)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Moderate strength allele.

      (Miyazaki and Orr-Weaver, 1992)

      Does not interact with ord4 to alter the male or female meiotic chromosome segregation phenotype.

      (Bickel et al., 1996)

      Moderate ord mutation.

      (Bickel et al., 1997)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      ord6
      Name Synonyms
      Secondary FlyBase IDs
        References (5)