a component of the chromosome passenger complex - regulates activity of Aurora B kinase through a positive-feedback loop - as a microtubule-binding protein Incenp has a well-defined centromere-targeting domain at its N-terminus, suggesting a role in targeting the kinase to particular locations within the mitotic cell
Gene model reviewed during 5.48
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.55
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Incenp using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Incenp in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Incenp CG12165
Source for merge of Incenp anon-WO0118547.171 was sequence comparison ( date:051113 ).
Incenp has a role in the maintenance of the synaptonemal complex during female meiosis and in the biorientation of bivalent chromosomes in prometaphase I.
Incenp has a role in two steps in spindle formation in female meiosis; the first is to assemble spindle microtubules around chromosomes and the second is to stabilise the spindle equatorial region to maintain spindle bipolarity.
RNAi screen using dsRNA made from templates generated with primers directed against this gene causes defects in spindle shape when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA.
Area matching Drosophila genomic sequence AC005452. EST AA979503 matches this genomic sequence 181bp 3' to NPS0227.