FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Incenp
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General Information
Symbol
Dmel\Incenp
Species
D. melanogaster
Name
Inner centromere protein
Annotation Symbol
CG12165
Feature Type
protein_coding_gene
FlyBase ID
FBgn0260991
Gene Model Status
Current
Stock Availability
10 publicly available
Gene Summary
Inner centromere protein (Incenp) encodes a component of the chromosomal passenger complex, acting as a subunit that targets and activates the product of aurB. It controls different processes during cell division, including regulation of chromosome structure, kinetochore-microtubule error correction, chromosome segregation and cytokinesis. [Date last reviewed: 2019-02-28] (FlyBase Gene Snapshot)
All Summaries
Also Known As

DmINCENP

Key Links
Genomic Location
Cytogenetic map
43A2-43A3
Sequence location
Recombination map
2-55
RefSeq locus
NT_033778 REGION:7278467..7281795
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (21 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables microtubule binding
inferred from direct assay
(Adams et al., 2001)
enables protein binding
inferred from physical interaction with FLYBASE:aurB; FB:FBgn0024227
(Adams et al., 2001)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables molecular function activator activity
inferred from biological aspect of ancestor with PANTHER:PTN009006245
(GO Reference Genome Project, 2011-)
Biological Process (8 terms)
Terms Based on Experimental Evidence (8 terms)
CV Term
Evidence
References
involved_in asymmetric cell division
inferred from mutant phenotype
(Chang et al., 2006)
involved_in intracellular protein localization
inferred from mutant phenotype
(Adams et al., 2001)
involved_in male meiosis sister chromatid cohesion
inferred from mutant phenotype
(Resnick et al., 2006)
involved_in meiotic chromosome condensation
inferred from mutant phenotype
(Resnick et al., 2006)
involved_in meiotic spindle midzone assembly
inferred from mutant phenotype
(Colombié et al., 2008)
involved_in metaphase chromosome alignment
inferred from mutant phenotype
(Adams et al., 2001)
involved_in mitotic cytokinesis
inferred from mutant phenotype
(Chang et al., 2006)
involved_in spindle assembly involved in female meiosis
inferred from mutant phenotype
(Colombié et al., 2008)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in meiotic spindle midzone assembly
inferred from biological aspect of ancestor with PANTHER:PTN009006245
(GO Reference Genome Project, 2011-)
involved_in metaphase chromosome alignment
inferred from biological aspect of ancestor with PANTHER:PTN009006245
(GO Reference Genome Project, 2011-)
involved_in mitotic cytokinesis
inferred from biological aspect of ancestor with PANTHER:PTN009006245
(GO Reference Genome Project, 2011-)
Cellular Component (10 terms)
Terms Based on Experimental Evidence (9 terms)
CV Term
Evidence
References
part_of chromosome passenger complex
inferred from direct assay
(Capalbo et al., 2012)
located_in chromosome, centromeric region
inferred from direct assay
(Orr and Sunkel, 2011, Resnick et al., 2006)
located_in chromosome
inferred from direct assay
(Resnick et al., 2006)
colocalizes_with condensed chromosome
inferred from direct assay
(Adams et al., 2001)
located_in kinetochore
inferred from direct assay
(Szafer-Glusman et al., 2011)
located_in meiotic spindle midzone
inferred from direct assay
(Szafer-Glusman et al., 2011)
colocalizes_with midbody
inferred from direct assay
(Adams et al., 2001)
located_in mitotic spindle midzone
inferred from direct assay
(Szafer-Glusman et al., 2011)
located_in spindle midzone
inferred from direct assay
(Resnick et al., 2006, Jang et al., 2005)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
part_of chromosome passenger complex
inferred from biological aspect of ancestor with PANTHER:PTN000994130
(GO Reference Genome Project, 2011-)
is_active_in kinetochore
inferred from biological aspect of ancestor with PANTHER:PTN000994130
(GO Reference Genome Project, 2011-)
is_active_in meiotic spindle midzone
inferred from biological aspect of ancestor with PANTHER:PTN000994130
(GO Reference Genome Project, 2011-)
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000994130
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
    -
    Summaries
    Gene Snapshot
    Inner centromere protein (Incenp) encodes a component of the chromosomal passenger complex, acting as a subunit that targets and activates the product of aurB. It controls different processes during cell division, including regulation of chromosome structure, kinetochore-microtubule error correction, chromosome segregation and cytokinesis. [Date last reviewed: 2019-02-28]
    Gene Group (FlyBase)
    MITOTOIC CHROMOSOMAL PASSENGER COMPLEX -
    The Mitotic Chromosomal Passenger Complex plays several key roles in mitosis including kinetochore-microtubule attachment, spindle assembly and cytokinesis. (Adapted from FBrf0216422 and FBrf0202888).
    MEIOTIC CHROMOSOMAL PASSENGER COMPLEX -
    The Meiotic Chromosomal Passenger Complex plays several key roles in meiosis including kinetochore-microtubule attachment, spindle assembly and cytokinesis. (Adapted from FBrf0216422 and FBrf0202888).
    Summary (Interactive Fly)

    a component of the chromosome passenger complex - regulates activity of Aurora B kinase through a positive-feedback loop - as a microtubule-binding protein Incenp has a well-defined centromere-targeting domain at its N-terminus, suggesting a role in targeting the kinase to particular locations within the mitotic cell

    Gene Model and Products
    Number of Transcripts
    3
    Number of Unique Polypeptides
    2

    Please see the JBrowse view of Dmel\Incenp for information on other features

    To submit a correction to a gene model please use the Contact FlyBase form

    Protein Domains (via Pfam)
    Isoform displayed:
    Pfam protein domains
    InterPro name
    classification
    start
    end
    Protein Domains (via SMART)
    Isoform displayed:
    SMART protein domains
    InterPro name
    classification
    start
    end
    Structure
    Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q7JRJ9)

    If you don't see a structure in the viewer, refresh your browser.
    Model Confidence:
    • Very high (pLDDT > 90)
    • Confident (90 > pLDDT > 70)
    • Low (70 > pLDDT > 50)
    • Very low (pLDDT < 50)

    AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

    Experimentally Determined Structures
    Crossreferences
    Comments on Gene Model

    Gene model reviewed during 5.48

    Low-frequency RNA-Seq exon junction(s) not annotated.

    Gene model reviewed during 5.55

    Transcript Data
    Annotated Transcripts
    Name
    FlyBase ID
    RefSeq ID
    Length (nt)
    Assoc. CDS (aa)
    Incenp-RA
    FBtr0088961
    NM_078924
    2699
    755
    Incenp-RB
    FBtr0336908
    NM_001273833
    2459
    755
    Incenp-RC
    FBtr0344892
    NM_001299227
    2595
    754
    Additional Transcript Data and Comments
    Reported size (kB)
    Comments
    External Data
    Crossreferences
    Polypeptide Data
    Annotated Polypeptides
    Name
    FlyBase ID
    Predicted MW (kDa)
    Length (aa)
    Theoretical pI
    UniProt
    RefSeq ID
    GenBank
    Incenp-PA
    FBpp0088035
    83.5
    755
    9.99
    Q7JRJ9
    NP_523648
    AAF59275
    Incenp-PB
    FBpp0307848
    83.5
    755
    9.99
    Q7JRJ9
    NP_001260762
    AGB93295
    Incenp-PC
    FBpp0311203
    83.4
    754
    9.99
    A0A0B4LFQ2
    NP_001286156
    AHN55954
    Polypeptides with Identical Sequences

    The group(s) of polypeptides indicated below share identical sequence to each other.

    755 aa isoforms: Incenp-PA, Incenp-PB
    Additional Polypeptide Data and Comments
    Reported size (kDa)
    Comments
    External Data
    Crossreferences
    Linkouts
    Sequences Consistent with the Gene Model
    Mapped Features

    Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Incenp using the Feature Mapper tool.

    External Data
    Crossreferences
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Linkouts
    Expression Data
    Testis-specificity index

    The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

    2.15

    Transcript Expression
    Additional Descriptive Data
    Marker for
     
    Subcellular Localization
    CV Term
    Polypeptide Expression
    Additional Descriptive Data
    Marker for
     
    Subcellular Localization
    CV Term
    Evidence
    References
    part_of chromosome passenger complex
    inferred from direct assay
    (Capalbo et al., 2012)
    located_in chromosome, centromeric region
    inferred from direct assay
    (Orr and Sunkel, 2011, Resnick et al., 2006)
    located_in chromosome
    inferred from direct assay
    (Resnick et al., 2006)
    colocalizes_with condensed chromosome
    inferred from direct assay
    (Adams et al., 2001)
    located_in kinetochore
    inferred from direct assay
    (Szafer-Glusman et al., 2011)
    located_in meiotic spindle midzone
    inferred from direct assay
    (Szafer-Glusman et al., 2011)
    colocalizes_with midbody
    inferred from direct assay
    (Adams et al., 2001)
    located_in mitotic spindle midzone
    inferred from direct assay
    (Szafer-Glusman et al., 2011)
    located_in spindle midzone
    inferred from direct assay
    (Resnick et al., 2006, Jang et al., 2005)
    Expression Deduced from Reporters
    High-Throughput Expression Data
    Associated Tools

    JBrowse - Visual display of RNA-Seq signals

    View Dmel\Incenp in JBrowse
    RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
    Bulk Downloads
    RNA-Seq RPKM values for all genes
    Reference
    See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
    Developmental Proteome: Life Cycle
    Developmental Proteome: Embryogenesis
    External Data and Images
    Linkouts
    DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
    EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    Images
    FlyBase Wiki
    Image Based Resources
    Alleles, Insertions, Transgenic Constructs, and Aberrations
    Classical and Insertion Alleles ( 6 )
    For All Classical and Insertion Alleles Show
     
    Other relevant insertions
    Transgenic Constructs ( 19 )
    For All Alleles Carried on Transgenic Constructs Show
    Transgenic constructs containing/affecting coding region of Incenp
    Transgenic constructs containing regulatory region of Incenp
    Aberrations (Deficiencies and Duplications) ( 1 )
    Inferred from experimentation ( 1 )
    Gene disrupted in
    Df(2R)pk78k
    (Chang et al., 2006)
    Inferred from location ( 3 )
    Variants
    Variant Molecular Consequences
    Alleles Representing Disease-Implicated Variants
    Phenotypes
    For more details about a specific phenotype click on the relevant allele symbol.
    Lethality
    Allele
    lethal
    lethal, with Scer\GAL4insc-Mz1407
    lethal - all die during embryonic stage
    lethal - all die during embryonic stage (with IncenpEC3747)
    lethal - all die during embryonic stage (with IncenpEP2340)
    lethal - all die during embryonic stage | non-rescuable maternal effect | recessive
    partially lethal, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
    viable
    viable, with Scer\GAL4Mef2.PR
    viable, with Scer\GAL4pnr-MD237
    Sterility
    Allele
    female fertile, with Scer\GAL4VP16.mat.αTub67C
    female semi-fertile, with IncenpGL00279, Scer\GAL4VP16.mat.αTub67C
    female semi-fertile, with IncenpΔSTD.RR.UASp, Scer\GAL4VP16.mat.αTub67C
    female semi-fertile, with Scer\GAL4VP16.mat.αTub67C
    female semi-sterile, with IncenpGL00279, Scer\GAL4VP16.mat.αTub67C
    female semi-sterile, with IncenpUASp.RR.Tag:FLAG, Scer\GAL4VP16.mat.αTub67C
    female semi-sterile, with IncenpUASp.RR.Tag:HA, Scer\GAL4VP16.mat.αTub67C
    female semi-sterile, with IncenpUASp.RR.Tag:MYC, Scer\GAL4VP16.mat.αTub67C
    female semi-sterile, with Scer\GAL4VP16.mat.αTub67C
    female sterile, with IncenpGL00279, Scer\GAL4VP16.mat.αTub67C
    female sterile, with IncenpINbox.UASp.Tag:MYC, Scer\GAL4VP16.mat.αTub67C
    female sterile, with IncenpΔCEN.RR.UASp, Scer\GAL4VP16.mat.αTub67C
    female sterile, with IncenpΔHP1.RR.UASp, Scer\GAL4VP16.mat.αTub67C
    female sterile, with IncenpΔSAH.RR.UASp, Scer\GAL4VP16.mat.αTub67C
    female sterile, with Scer\GAL4VP16.mat.αTub67C
    female sterile | recessive
    male semi-sterile
    semi-fertile
    semi-sterile | dominant
    sterile | female
    Other Phenotypes
    Allele
    abnormal cell cycle
    abnormal locomotor rhythm
    abnormal meiotic cell cycle
    abnormal meiotic cell cycle | oogenesis
    abnormal meiotic cell cycle | oogenesis, with IncenpEC3747, Scer\GAL4VP16.nanos.UTR
    abnormal meiotic cell cycle | oogenesis, with IncenpGL00279, Scer\GAL4VP16.mat.αTub67C
    abnormal meiotic cell cycle | oogenesis, with IncenpUASp.RR.Tag:FLAG, Scer\GAL4VP16.mat.αTub67C
    abnormal meiotic cell cycle | oogenesis, with IncenpUASp.RR.Tag:HA, Scer\GAL4VP16.mat.αTub67C
    abnormal meiotic cell cycle | oogenesis, with IncenpUASp.RR.Tag:MYC, Scer\GAL4VP16.mat.αTub67C
    abnormal meiotic cell cycle | oogenesis, with IncenpUASp.Tag:MYC, Scer\GAL4VP16.nanos.UTR
    abnormal meiotic cell cycle | oogenesis, with IncenpΔSTD.RR.UASp, Scer\GAL4VP16.mat.αTub67C
    abnormal meiotic cell cycle | oogenesis, with Scer\GAL4VP16.mat.αTub67C
    abnormal meiotic cell cycle | oogenesis, with Scer\GAL4VP16.nanos.UTR
    abnormal mitotic cell cycle | larval stage
    abnormal neuroanatomy
    abnormal neuroanatomy | larval stage, with Scer\GAL4insc-Mz1407
    some die during embryonic stage
    some die during embryonic stage (with IncenpEC3747)
    some die during embryonic stage (with IncenpEP2340)
    some die during embryonic stage | recessive
    visible, with Scer\GAL4en-e16E
    visible, with Scer\GAL4ey.PH
    visible, with Scer\GAL4pnr-MD237
    Phenotype manifest in
    Allele
    chromosome & meiotic primary spermatocyte
    chromosome & meiotic secondary spermatocyte
    chromosome passenger complex | female
    chromosome passenger complex | oogenesis, with IncenpGL00279, Scer\GAL4VP16.mat.αTub67C
    chromosome passenger complex | oogenesis, with IncenpUASp.RR.Tag:HA, Scer\GAL4VP16.mat.αTub67C
    chromosome passenger complex | oogenesis, with IncenpUASp.RR.Tag:MYC, Scer\GAL4VP16.mat.αTub67C
    embryo | embryonic stage 5
    eye
    eye, with Scer\GAL4ey.PH
    female germline cyst, with Scer\GAL4VP16.nanos.UTR
    ganglion mother cell | larval stage, with Scer\GAL4insc-Mz1407
    larval neuroblast | larval stage, with Scer\GAL4insc-Mz1407
    meiotic spindle | female
    meiotic spindle | oogenesis, with IncenpGL00279, Scer\GAL4VP16.mat.αTub67C
    meiotic spindle | oogenesis, with IncenpΔCEN.RR.UASp, Scer\GAL4VP16.mat.αTub67C
    meiotic spindle | oogenesis, with Scer\GAL4VP16.mat.αTub67C
    mesonotum, with Scer\GAL4pnr-MD237
    nucleus
    onion stage spermatid
    oocyte
    oocyte, with IncenpEC3747, Scer\GAL4VP16.nanos.UTR
    oocyte, with IncenpGL00279, Scer\GAL4VP16.mat.αTub67C
    oocyte, with IncenpUASp.RR.Tag:HA, Scer\GAL4VP16.mat.αTub67C
    oocyte, with IncenpUASp.RR.Tag:MYC, Scer\GAL4VP16.mat.αTub67C
    oocyte, with IncenpUASp.Tag:MYC, Scer\GAL4VP16.nanos.UTR
    oocyte, with IncenpΔCEN.RR.UASp, Scer\GAL4VP16.mat.αTub67C
    oocyte, with Scer\GAL4VP16.mat.αTub67C
    oocyte, with Scer\GAL4VP16.nanos.UTR
    oocyte | oogenesis stage S12
    oocyte | oogenesis stage S13
    presumptive embryonic/larval peripheral nervous system
    spindle
    spindle microtubule | oogenesis, with Scer\GAL4VP16.mat.αTub67C
    spindle midzone & oocyte
    spindle pole & oocyte
    wing
    wing blade posterior compartment, with Scer\GAL4en-e16E
    Orthologs
    Downloads
    Download All DIOPT Orthologs
    Human Orthologs (via DIOPT v9.1)
    Species\Gene Symbol
    Score
    Best Score
    Best Reverse Score
    Source
    Compara
    Domainoid
    eggNOG
    Hieranoid
    Homologene
    Inparanoid
    OMA
    OrthoDB
    OrthoFinder
    OrthoInspector
    orthoMCL
    Panther
    Phylome
    SonicParanoid
    Alignment
    Complementation?
    Transgene?
    Homo sapiens (Human) (1)
    Hsap\INCENP
    6 of 14
    Yes
    Yes
    Model Organism Orthologs (via DIOPT v9.1)
    Species\Gene Symbol
    Score
    Best Score
    Best Reverse Score
    Source
    Compara
    Domainoid
    eggNOG
    Hieranoid
    Homologene
    Inparanoid
    OMA
    OrthoDB
    OrthoFinder
    OrthoInspector
    orthoMCL
    Panther
    Phylome
    SonicParanoid
    Alignment
    Complementation?
    Transgene?
    Rattus norvegicus (Norway rat) (1)
    Rnor\Incenp
    6 of 14
    Yes
    Yes
    Mus musculus (laboratory mouse) (1)
    Mmus\Incenp
    5 of 14
    Yes
    Yes
    Xenopus tropicalis (Western clawed frog) (1)
    Xtro\incenp
    4 of 13
    Yes
    Yes
    Danio rerio (Zebrafish) (1)
    Drer\incenp
    3 of 14
    Yes
    Yes
    Caenorhabditis elegans (Nematode, roundworm) (1)
    Cele\icp-1
    3 of 14
    Yes
    Yes
    Anopheles gambiae (African malaria mosquito) (1)
    Agam\AgaP_AGAP011772
    7 of 12
    Yes
    Yes
    Arabidopsis thaliana (thale-cress) (0)
    Saccharomyces cerevisiae (Brewer's yeast) (0)
    Schizosaccharomyces pombe (Fission yeast) (0)
    Escherichia coli (enterobacterium) (0)
    Other Organism Orthologs (via OrthoDB)
    Data provided directly from OrthoDB:Incenp. Refer to their site for version information.
    Paralogs
    Downloads
    Download All DIOPT Paralogs
    Paralogs (via DIOPT v9.1)
    Human Disease Associations
    FlyBase Human Disease Model Reports
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Allele
      Disease
      Evidence
      References
      Potential Models Based on Orthology ( 0 )
      Human Ortholog
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Allele
      Disease
      Interaction
      References
      Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
      Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
      Homo sapiens (Human)
      Gene name
      Score
      OMIM
      OMIM Phenotype
      DO term
      Complementation?
      Transgene?
      INCENP; inner centromere protein
      6 of 14
      604411
          Functional Complementation Data
          Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
          Interactions
          Summary of Physical Interactions
          Summary of Genetic Interactions
          Interaction Browsers
          View in FlyBase Interactions Browser   View in MIST tool (external link)
          Please look at the allele data for full details of the genetic interactions
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          Incenp
          suppressible
          borr::Incenp
          (Wang et al., 2021)
          Incenp
          suppressible
          CycE
          (Tseng and Hariharan, 2002)
          Incenp
          enhanceable
          ord
          (Resnick et al., 2009)
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          Det
          suppressible
          Incenp
          (Mathieu et al., 2013)
          Myt1
          suppressible
          Incenp
          (Willms et al., 2020)
          sub
          enhanceable
          Incenp
          (Cesario et al., 2006)
          yki
          enhanceable
          Incenp
          (Gerlach et al., 2018)
          External Data
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          DroID - A comprehensive database of gene and protein interactions.
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Pathways
          Signaling Pathways (FlyBase)
          Metabolic Pathways
          FlyBase
          External Links
          External Data
          Linkouts
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          Class of Gene
          Genomic Location and Detailed Mapping Data
          Chromosome (arm)
          2R
          Recombination map
          2-55
          Cytogenetic map
          43A2-43A3
          Sequence location
          FlyBase Computed Cytological Location
          Cytogenetic map
          Evidence for location
          43A2-43A3
          Limits computationally determined from genome sequence between P{lacW}vimark16722 and P{lacW}cosk16101
          Experimentally Determined Cytological Location
          Cytogenetic map
          Notes
          References
          Experimentally Determined Recombination Data
          Location

          2-55

          (FlyBase, 2016)

          2-56.3

          (Comeron et al., 2012)

          2-61

          (Schupbach and Wieschaus, 1989)
          Left of (cM)
          Right of (cM)
          Notes
          Stocks and Reagents
          Stocks (10)
          Genomic Clones (21)
          cDNA Clones (95)
           

          Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

          cDNA clones, fully sequenced
          BDGP DGC clones
          Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          Antibody Information
          Laboratory Generated Antibodies
           
          Commercially Available Antibodies
           
          Cell Line Information
          Publicly Available Cell Lines
           
            Other Stable Cell Lines
             
              Other Comments

              Incenp has a role in the maintenance of the synaptonemal complex during female meiosis and in the biorientation of bivalent chromosomes in prometaphase I.

              (Resnick et al., 2009)

              Incenp has a role in two steps in spindle formation in female meiosis; the first is to assemble spindle microtubules around chromosomes and the second is to stabilise the spindle equatorial region to maintain spindle bipolarity.

              (Colombié et al., 2008)

              RNAi screen using dsRNA made from templates generated with primers directed against this gene causes defects in spindle shape when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA.

              (Goshima et al., 2007)

              Area matching Drosophila genomic sequence AC005452. EST AA979503 matches this genomic sequence 181bp 3' to NPS0227.

              (Davies, 2001.3.15)

              Mutation in mat(2)ea-C results in a strict maternal effect phenotype with defects during presyncytial stages.

              (Schupbach and Wieschaus, 1989)
              Relationship to Other Genes
              Source for database merge of

              Source for merge of: Incenp mat(2)ea-C

              (Resnick et al., 2006)

              Source for merge of: Incenp anon-WO0118547.171

              (FlyBase, 1996-)
              Additional comments

              Source for merge of Incenp anon-WO0118547.171 was sequence comparison ( date:051113 ).

              (FlyBase, 1996-)
              Nomenclature History
              Source for database identify of

              Source for identity of: Incenp CG12165

              (Adams et al., 2001)
              Nomenclature comments
              Etymology
              Synonyms and Secondary IDs (13)
              Reported As
              Symbol Synonym
              CG12165
              (National Institute of Genetics Fly Stocks, 2022-, Hosono et al., 2015, Fukuoh et al., 2014, Moutinho-Pereira et al., 2013, Schertel et al., 2013, Ni et al., 2011.7.19, Keleman et al., 2009.8.5, Goshima et al., 2007, Arruda and Dolph, 2003, Dimova et al., 2003, Adams et al., 2001)
              DmINCENP
              (Gao et al., 2008, Chang et al., 2003, Adams et al., 2001, Adams et al., 2001)
              INCENP
              (Shapiro et al., 2025, Park et al., 2019, Alekseyenko et al., 2014, Carmena et al., 2014, Noatynska et al., 2013, Capalbo et al., 2012, Carmena et al., 2012, Crest et al., 2012, Giansanti et al., 2012, McKee et al., 2012, Chen et al., 2011, Szafer-Glusman et al., 2011, Royou et al., 2010, Long et al., 2008, Pandey et al., 2007, Hediger and Gasser, 2006, D'Avino et al., 2005, Kramer and Hawley, 2005, Hickson et al., 2003, Bownes et al., 2002, Adams et al., 2001)
              Incenp
              (Vesala et al., 2024, Khalili et al., 2023, Repton et al., 2022, Cattenoz et al., 2021, Wang et al., 2021, Karman et al., 2020, Meyer-Nava et al., 2020, Willms et al., 2020, Costa and Ohkura, 2019, Rotelli et al., 2019, Cho et al., 2018, Hughes et al., 2018, Das et al., 2016, Bischof, 2014.10.20, Liang et al., 2014, Bonke et al., 2013, Kwon et al., 2013, Moutinho-Pereira et al., 2013, Schertel et al., 2013, Thomae et al., 2013, Carmena et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Joyce et al., 2012, Korenjak et al., 2012, Radford et al., 2012, Radford et al., 2012, Friedman et al., 2011, Neumüller et al., 2011, Lemos et al., 2010, D'Avino et al., 2009, Hughes et al., 2009, Cesario and McKim, 2008, Somma et al., 2008, Wu et al., 2008, Gilliland et al., 2007, Gilliland et al., 2007, Goshima et al., 2007, Cesario et al., 2006, Chang et al., 2006, De Lucia et al., 2005, Jang et al., 2005)
              anon-WO0118547.171
              dIncenp
              (Hanson and Bienz, 2005)
              incenp
              (Mathieu et al., 2013, Li et al., 2010, Resnick et al., 2009, Colombié et al., 2008, Jang et al., 2006, Resnick et al., 2006)
              mat(2)ea-C
              mat(2)earlyQA26
              (Schupbach and Wieschaus, 1989)
              Name Synonyms
              Inner Centromere Protein
              (Giansanti et al., 2012, Szafer-Glusman et al., 2011)
              Inner centromere protein
              (Ahmad et al., 2012, Lemos et al., 2010, Long et al., 2008, Adams et al., 2001)
              inner centromere protein
              (Crest et al., 2012, Pandey et al., 2007)
              maternal effect early arrest C
              Secondary FlyBase IDs
              • FBgn0033156
              • FBgn0062193
              • FBgn0002666
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              Study result (0)
              Result
              Result Type
              Title
              External Crossreferences and Linkouts ( 51 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
              Other crossreferences
              AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
              DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
              EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
              FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
              KEGG Genes - Molecular building blocks of life in the genomic space.
              MARRVEL_MODEL - MARRVEL (model organism gene)
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
              Flygut - An atlas of the Drosophila adult midgut
              FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
              References (128)