FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\IncenpEC3747
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General Information
Symbol
Dmel\IncenpEC3747
Species
D. melanogaster
Name
FlyBase ID
FBal0221166
Feature type
allele
Associated gene
Dmel\Incenp
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Chang et al., 2006)
Progenitor genotype
Cytology
Description

Amino acid replacement: Q457term.

(Chang et al., 2006)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:7,280,291..7,280,291 [+]
Nucleotide change:

C7280291T

Reported nucleotide change:

C?T

Amino acid change:

Q458term | Incenp-PA; Q458term | Incenp-PB; Q458term | Incenp-PC

Reported amino acid change:

Q457term

(Chang et al., 2006)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of IncenpUASp.Tag:MYC under the control of Scer\GAL4VP16.nos.UTR leads to abnormal chromosome segregation (including missegregation of both chiasmate and achiasmate X chromosomes) in oocytes although a bipolar spindle forms in most of the oocytes as compared to controls. There are more severe defects in a IncenpEC3747 background.

      (Radford et al., 2012)

      IncenpEC3747 mutant first larval instar escapers show reduced mobility and abnormal wandering behaviour.

      Heterozygous IncenpEC3747 mutants exhibit a wild-type neural pattern in the PNS.

      Homozygous IncenpEC3747 mutants exhibit a range of neural defects in the PNS, from severe cases of neuronal loss to perturbation of the neural clusters and missing subsets of neurons.

      There appears to be no difference between IncenpEC3747 mutant and wild-type embryos during the first 13 rapid synchronous cycles. IncenpEC3747 embryos show no defect in cellularization. There are no defects in early-stage embryos, although from mitotic cycle 15, a very low percentage of cells exhibit chromosome segregation defects. By embryonic stage 13, cells in the central nervous system show enlarged nuclei and bigger or multiple centrosomes compared with wild-type.

      IncenpEC3747 neuroblasts exhibit defects in the shape and orientation of the basal pros cresent.

      (Chang et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      IncenpEC3747/Incenp[+] is an enhancer of abnormal mitotic cell cycle phenotype of sub131/sub1

      (Cesario et al., 2006)
      Other
      Statement
      Reference

      IncenpEC3747/Incenp[+], sub131/sub1 has lethal | larval stage phenotype

      (Cesario et al., 2006)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      sub1/sub131, IncenpEC3747/+ mutant larval brains display defects in spindle assembly, and short and disorganised metaphase spindles are common. Anaphase spindles usually lack an organised midzone, and 76% show lagging chromosomes at anaphase (compared to 55% in sub1/sub131 mutant brains). Double mutant larvae exhibit a high frequency of polyploid cells.

      (Cesario et al., 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      IncenpQA26

      (Colombié et al., 2008)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      IncenpEC3747
      (Cesario et al., 2006, Chang et al., 2006)
      incenp3747
      (Colombié et al., 2008)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)