Dub, mei-1794, Double or nothing, Mklp2
Gene model reviewed during 5.50
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\sub using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\sub in GBrowse 2
Mapping based on 33 recombinants.
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in S2R+ cells: cell morphology is aberrant and there is an increased frequency of microtubule-based mitotic spindles, indicative of a failure in mitosis. This phenotype is not seen in Kc167 cells.
Identification: genetic screen for meiotic mutants.
Required for spindle assembly during meiosis, and specifically, the formation of the two spindle poles.
Mutants show defective meiosis.
sub is unusual in that mutations cause aberrant chromosome segregation almost exclusively in meiosis I in both sexes.