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FB2026_01
,
released March 12, 2026
KLP38B, 38B.10, 38B.12, tio, Mothra
Please see the JBrowse view of Dmel\neb for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.43
Gene model reviewed during 5.52
3.6 (longest cDNA)
3.6 (northern blot)
3.5 (northern blot)
There is only one protein coding transcript and one polypeptide associated with this gene
1121 (aa)
1121 (aa); 125 (kD predicted)
1121 (aa); 110 (kD observed)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\neb using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
neb is expressed in proliferating cells in various tissues and developmental stages, including the central nervous system, imaginal discs, testis, and ovary.
The neb transcript is most abundant in 0-2 hr embryos, and is also present in later embryos and in adults. In situ analysis shows that neb is distributed uniformly in preblastoderm embryos. neb is restricted to the nervous system at mid-embryogenesis, and is found in the procephalic neuroblasts and the ventral cord late in embryogenesis. During larval stages, expression is detected in the mitotically active regions of the brain and imaginal discs. From stage 5 of oogenesis, neb is detected in follicle cells and nurse cells. In th adult testis, neb accumulates in gonial cells and in primary spermatocytes.
neb is expressed at high levels in embryos. It is also expressed in adults during gametogenesis.
During mitosis and male meiosis, neb protein colocalizes with condensed chromatin.
JBrowse - Visual display of RNA-Seq signals
View Dmel\neb in JBrowse2-54
2-53.9
2-54.5
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
neb encodes the kinesin-like protein KLP38B.
neb, perhaps redundantly with other chromosome-associated microtubule motor proteins, contributes to interactions between chromosome arms and microtubules important for establishing bipolar attachment of chromosomes and assembly of stable bipolar spindles.
neb has been cloned and sequenced.
Mutations in neb slow down blastoderm mitotic divisions.
neb is required during mitosis for chromosome placement or maintenance at the metaphase plate in blastoderm embryos.
Complementation group identified in the barr region.
Encodes a kinesin-like protein.
Mutations of neb affect the morphology and behaviour of the mitotic spindles of embryonic cleavage divisions to produce multipolar spindles in male meiosis and generate abnormal mitotic figures in larval neuroblasts.
The P{lacW}l(2)k09314bk09314b insertion maps between pr and neb, mapping between the predicted neb promoter and transcription start site.
"l(2)k09314b" probably corresponds to "neb".
Gene name "Mothra" was named after the insect monster that protected Tokyo from Godzilla. Name is based on the nebMot embryonic phenotype.
