FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\sevB4
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General Information
Symbol
Dmel\sevB4
Species
D. melanogaster
Name
FlyBase ID
FBal0032689
Feature type
allele
Associated gene
Dmel\sev
Associated Insertion(s)
Carried in Construct
P{sevB4}
Key Links
Transgenic product class
missense_variant
(Simon et al., 1991)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Simon et al., 1991)
Mutagen
P-element activity
(Simon et al., 1993)
in vitro construct
(Simon et al., 1991)
Progenitor genotype
Carried in construct
P{sevB4}
Cytology
Description

Construct: Replacement Arginine for Histidine and Tyrosine for Histidine, unknown positions.

(Simon et al., 1991)
Allele components
Component
Use(s)
Encoded product / tool
sev
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      At 23oC some ommatidia lack the R7 rhabdomere.

      (Simon et al., 1993)

      At 22.7oC the reduced corneal pseudopupils of flies are wild type, at 24.3oC the reduced corneal pseudopupil is lacking the R7 cell.

      (Simon et al., 1991)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      sevB4 has phenotype, enhanceable by E(sev)3De0Q

      (Hiromi and Butler, 1997.3.8)

      sevB4 has photoreceptor cell R7 phenotype, enhanceable by drke0A

      (Simon et al., 1993)

      sevB4 has phenotype, enhanceable by Cdc37[+]/Cdc37e1C

      (Simon et al., 1991)

      sevB4 has phenotype, enhanceable by Cdc37[+]/Cdc37e1E

      (Simon et al., 1991)

      sevB4 has phenotype, enhanceable by Cdc37[+]/Cdc37e4D

      (Simon et al., 1991)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      In the presence of drkE(sev)2B nearly all of the sevB4 ommatidia lack the R7 cell. The presence of P{sev-drk} restores an R7 cell to most ommatidia.

      (Simon et al., 1993)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      sevB4
      Name Synonyms
      Secondary FlyBase IDs
        References (5)