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General Information
Symbol
Dmel\rhoPΔ5
Species
D. melanogaster
Name
FlyBase ID
FBal0033087
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Deletion removing whole of P{lwB}X81 and extending to between 88 nucleotides 3' of the presumed initiating ATG and 267 nucleotides 3' to this ATG.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Marker expression analysis shows that rhoPΔ5 homozygous eyes (generated using 'ey-FLP' + Scer\FRT) the proportion of pale-ommatidia is reduced and hybrid ommatidia are present with a yellow-type R8 and a pale-type R7. In eyes that are a mosaic of rhoPΔ5 homozygous, heterozygous and wild-type clones, there is a significant decrease in the proportion of pale-type R8 cells in pale ommatidia in ommatidia where both R8 are R7 are not rhoPΔ5 homozygous. This proportion is not significantly different in ommatidia with a rhoPΔ5 homozygous R7 and wild-type of heterozygous R8, but is decreased significantly more in ommatidia with a rhoPΔ5 homozygous R8, irrespective of the genotype of R7.

The tracheal system of rhoPΔ5 embryos show branch interruptions and branches with cells only connected by cytoplasmic extensions. The tracheal tubes of stage 16 rhoPΔ5 embryos show a thinner accumulation of cortical actin compared to controls.

Ommatidia in homozygous clones sometimes have missing photoreceptor cells.

Homozygous clones in the adult abdomen do not show any consistent alterations of normal polarity.

The number of chordotonal organs in the lateral cluster is reduced from 5 to 3 in stage 16 homozygous embryos and there is a complete lack of oenocytes. Oenocyte precursor whorls are missing in stage 11 embryos.

Homozygous embryos show a variable tracheal phenotype consisting mostly of defects in migration along the anteroposterior axis. The dorsal trunk and visceral branches are missing or incomplete. Some tracheal cells remain in the ectoderm at stage 12 in contrast to wild type.

Embryos show normal guts.

No effect on the faf eye phenotype.

Germline clone experiments show that rho has no function in oogenesis.

Defects in embryonic head skeleton, and characteristic fusions of denticle belts.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
NOT Suppressor of
Statement
Reference
Other
Additional Comments
Genetic Interactions
Statement
Reference

Although extra wing vein material is induced in Gug14967 clones, wing vein differentiation is blocked in vn10567 rhoPΔ5 Gug14967 triple mutant clones.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Fails to complement rho7M43.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (7)
References (21)