FlyBase Allele Report: Dmel\Ca-α1D[X10]

General Information

Symbol

Dmel\Ca-α1D^X10

Species

D. melanogaster

Name

FlyBase ID

FBal0033485

Feature type

allele

Associated gene

Dmel\Ca-α1D

Associated Insertion(s)

Carried in Construct

Also Known As

Dmca1D^X10

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - molecular evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Hsu et al., 2020)

Mutagen

ethyl methanesulfonate

(Ashburner et al., 1999.10.12, Roote, 1995.5.4)

Progenitor genotype

Cytology

Description

Mutation of a TaqI site from TCGA to TTGA, thereby changing an Arg codon to a stop codon. Residue resides in the cytoplasmic loop just following the IV-S4 transmembrane domain, producing a truncated protein missing the last two transmembrane domains (IV-S5 and IV-S6) and cytoplasmic carboxy tail.

(Eberl et al., 1998)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2L:16,183,977..16,183,977 [+]

Nucleotide change:

C16183977T

Amino acid change:

(Eberl et al., 1998)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Huntington's disease

modeled by Hsap\HTT^128Q.FL.UAS

(Romero et al., 2008)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neurophysiology | P-stage | somatic clone

(Kanamori et al., 2013)

lethal | recessive

(Ashburner et al., 1990)

lethal - all die during embryonic stage | recessive

(Eberl et al., 1998)

some die during embryonic stage | recessive

(Eberl et al., 1998)

Phenotype Manifest In

cephalopharyngeal skeleton

(Eberl et al., 1998)

embryonic/larval dorsal vessel | embryonic stage

(Eberl et al., 1998)

embryonic/larval midgut | embryonic stage

(Eberl et al., 1998)

larval multidendritic class IV neuron | P-stage | somatic clone

(Kanamori et al., 2013)

larval tracheal system

(Eberl et al., 1998)

Detailed Description

Statement

Reference

Mutants die at the late embryonic stage with no gross morphological abnormalities. The tracheae of mutant embryos generally do not become gas-filled. Embryos do move but the movements are very weak: slow localised twitches, usually at the posterior end. Some peristaltic motion is visible in the gut, this is very slow. Occasionally embryos bend their heads but movement of the cephalopharyngeal apparatus is not seen. Pumping of the heart is not seen.

(Eberl et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Ca-α1D^X10 has abnormal neurophysiology | P-stage | somatic clone phenotype, enhanceable by cac^HC129/cac^HC129

(Kanamori et al., 2013)

Enhancer of

Statement

Reference

Ca-α1D^X10/Ca-α1D^X10 is an enhancer of abnormal neurophysiology | P-stage | somatic clone phenotype of cac^HC129

(Kanamori et al., 2013)

Suppressor of

Statement

Reference

Ca-α1D^X10/Ca-alpha1D[+] is a suppressor of abnormal neurophysiology phenotype of Hsap\HTT^128Q.FL.UAS, Scer\GAL4^elav-C155

(Romero et al., 2008)

Other

Statement

Reference

Ca-α1D^X10, cac^HC129 has abnormal neuroanatomy | somatic clone | P-stage phenotype

(Kanamori et al., 2013)

Phenotype Manifest In

Enhanced by

Statement

Reference

Ca-α1D^X10 has larval multidendritic class IV neuron | P-stage | somatic clone phenotype, enhanceable by cac^HC129/cac^HC129

(Kanamori et al., 2013)

Enhancer of

Statement

Reference

Ca-α1D^X10/Ca-α1D^X10 is an enhancer of larval multidendritic class IV neuron | P-stage | somatic clone phenotype of cac^HC129

(Kanamori et al., 2013)

Suppressor of

Statement

Reference

Ca-α1D^X10/Ca-alpha1D[+] is a suppressor of rhabdomere of eye photoreceptor cell | conditional | adult stage phenotype of Hsap\HTT^128Q.FL.UAS, Scer\GAL4^GMR.PF

(Romero et al., 2008)

Other

Statement

Reference

Ca-α1D^X10, cac^HC129 has dendrite | somatic clone | P-stage phenotype

(Kanamori et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

Ca-α1D^X10 cac^20-3/Df(1)RC29 double mutant embryos show no defect in the number of varicosities or innervation pattern at the neuromuscular junction of muscle fibres 6 and 7.

(Rieckhof et al., 2003)

Xenogenetic Interactions

Statement

Reference

Ca-α1D^X10/+ reverses the increase in resting synaptic Ca[2+] levels at presynaptic terminals seen in Hsap\HD^{128Q.FL.Scer\UAS}, Scer\GAL4^elav-C155 larvae.

Ca-α1D^X10/+ significantly suppresses the increased excitatory junction potential (EJP) amplitude and decreased failure rate seen in Hsap\HD^{128Q.FL.Scer\UAS}, Scer\GAL4^elav-C155 animals at 0.25 mM Ca[2+].

Ca-α1D^X10/+ suppresses the reduced number of rhabdomeres per ommatidium phenotype seen in Hsap\HD^{128Q.FL.Scer\UAS}, Scer\GAL4^GMR.PF animals at 20 days.

(Romero et al., 2008)

Complementation and Rescue Data

Rescued by

Ca-α1D^X10 is rescued by Ca-α1D^+tCa01

(Eberl et al., 1998)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

25141

Adc^b-1 Ca-α1D^X10 pr¹ cn¹ wx^wxt bw¹/CyO

Notes on Origin

Discoverer

S. Roth.

(Roote, 1995.5.4)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Ca-α1D^X10

(Liu et al., 2022, Krick et al., 2021, Terada et al., 2016)

Dmca1D^X10

(Kurshan et al., 2009, Romero et al., 2008, Rieckhof et al., 2003, Eberl et al., 1998)

Dmca1D^x10

(Romero et al., 2008)

Dmca1DX10

(Hsu et al., 2020)

ca-α1D^x10

(Kanamori et al., 2013)

Name Synonyms

Secondary FlyBase IDs

References (13)

Report Sections

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