FlyBase Allele Report: Dmel\Doa[3B]

General Information

Symbol

Dmel\Doa^3B

Species

D. melanogaster

Name

FlyBase ID

FBal0033615

Feature type

allele

Associated gene

Dmel\Doa

Associated Insertion(s)

Carried in Construct

Also Known As

Doa^γ3B

Key Links

Allele class

loss of function allele

Mutagen

Nature of the Allele

Allele class

loss of function allele

(Yun et al., 2000)

Mutagen

gamma ray

(Rabinow et al., 1993)

137Cs gamma ray

(Kpebe and Rabinow, 2008)

Progenitor genotype

Caused by aberration

In(3R)Doa^3B

Cytology

Description

Breakpoint within an intron.

(Yun et al., 1994)

Cytological aberration of undetermined nature at 98F1-98F2.

(Rabinow et al., 1993)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

cell lethal | recessive | somatic clone

(Yun et al., 2000)

chemical resistant | dominant

(James et al., 2009)

lethal (with Df(3R)3450)

(Yun et al., 2000)

lethal (with Doa^01705b)

(Yun et al., 2000)

lethal | recessive

(Rabinow et al., 1993)

Phenotype Manifest In

egg chamber | germline clone

(Morris et al., 2003)

Detailed Description

Statement

Reference

Doa^3B heterozygous adults show significantly reduced sensitity to paraquat.

(James et al., 2009)

Homozygous germ cell clones die shortly after encapsulation by follicle cells, resulting in budded egg chambers of healthy follicle cells in which germ cells are absent or dying.

(Morris et al., 2003)

Homozygous clones induced 25-36 hours after egg laying are not recovered in eyes or adult cuticle, although wild-type twinspot clones are recovered in mosaic eyes. The morphology of the eye and cuticle is normal in these flies. When clones are induced in 4 to 6 day old larvae (late second through third instar), mosaic eyes containing wild-type twinspot clones are often rough. Photoreceptors and pigment cells are randomly missing, although no loss of specific cell types is seen. Even in apparently normal eyes, defects in the organisation of the retina are seen, presumably due to the death of homozygous mutant cells. Ommatidia near homozygous wild-type clones are often missing random photoreceptors in these flies. Flies with one or more bristles missing in the triple row of the anterior wing margin are also recovered. No homozygous mutant clones are detected, indicating that the mutant cells die even when clones are induced in the late third larval instar. Homozygous female germ line clones are unable to produce eggs.

(Yun et al., 2000)

Darkens w^a.

(Rabinow et al., 1993)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Doa^3B, E(gl)3C^unspecified has viable phenotype

(Yun et al., 2000)

Doa^3B, E(gl)3C^unspecified has fertile phenotype

(Yun et al., 2000)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Doa^3B in combination with E(gl)3C^unspecified results in flies with normal eyes, wings and bristles. No suppression of w^a is seen in these flies.

(Yun et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially complements

Doa^RemγA

(Yun et al., 2000)

Comments

Doa^3B only poorly complements In(3)Msu² or Doa^RemγA.

(Yun et al., 2000)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Doa^3B

Doa^γ3B

(James et al., 2009, Kpebe and Rabinow, 2008, Staatz et al., 2005, Morris et al., 2003, Yun et al., 2000, Yun et al., 1994)

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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