FB2026_02 , released June 18, 2026
Allele: Dmel\Gβ76C2
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General Information
Symbol
Dmel\Gβ76C2
Species
D. melanogaster
Name
FlyBase ID
FBal0033683
Feature type
allele
Associated gene
Dmel\Gβ76C
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
    Nature of the Allele
    Allele class

    hypomorphic allele - genetic evidence

    (Elia et al., 2005)
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: G288E.

    (Dolph et al., 1994)

    Single amino acid change.

    (Yarfitz et al., 1994)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    3L:19,689,287..19,689,287 [+]
    Nucleotide change:

    G19689287A

    Amino acid change:

    G288E | Gbeta76C-PA

    Reported amino acid change:

    G288E

    Comment:

    Site of nucleic acid difference in mutant inferred by FlyBase based on reported amino acid change.

    (Dolph et al., 1994)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Whole cell patch-clamp recording of dark-adapted Gβ76C2 mutant photoreceptor cells shows spontaneous, unitary, inward currents that are similar in shape to the single photon responses known as quantum bumps. Homozygous Gβ76C2 mutants exhibit an increase in bump frequency compared to wild-type.

        (Elia et al., 2005)

        Whole cell patch clamp recordings demonstrate photoreceptors have a dramatic loss of light sensitivity.

        (Dolph et al., 1994)

        Mutation does not cause retinal degradation, photoreceptors exhibit normal morphology. Light-dependent 35S-labelled guanosine 5'-3-0-(thio)triphosphate (35S GTPγS) binding is severely reduced.

        (Yarfitz et al., 1994)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        Gβ76C2 is rescued by Gβ76C+tDa

        (Dolph et al., 1994)
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        Comments
        Comments

        Reduction in levels of Gβ76C protein.

        (Dolph et al., 1994)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        Gβ76C2
        Gβe2
        (Elia et al., 2005)
        Name Synonyms
        Secondary FlyBase IDs
          References (3)