FB2026_03 , released September 17, 2026
Allele: Dmel\NΔEGF1-18.hs
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General Information
Symbol
Dmel\NΔEGF1-18.hs
Species
D. melanogaster
Name
FlyBase ID
FBal0033800
Feature type
allele
Associated gene
Dmel\N
Associated Insertion(s)
Carried in Construct
P{ΔEGF1-18}
Key Links
Transgenic product class
inframe_deletion
(Lieber et al., 1993)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Lieber et al., 1993)
Mutagen
in vitro construct
(Lieber et al., 1993)
Progenitor genotype
Carried in construct
P{ΔEGF1-18}
Cytology
Description

An Hsp70 promoter drives expression of an internally deleted form of N (deletion of EGF repeats 1-18).

(Lieber et al., 1993)
Allele components
Component
Use(s)
Regulatory region(s)
Hsp70
Encoded product / tool
N
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Males carrying NΔEGF1-18.hs reared at 25[o]C subjected to two 1 hour heat pulses per day, beginning 3 days post-eclosion, exhibit a significant decline in lifespan. Without the 37[o]C heat pulses, lifespan is unaffected.

      (Presente et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      NΔEGF1-18.hs fails to rescue Nl1N-ts1

      (Presente et al., 2004)

      NΔEGF1-18.hs fails to rescue Nl1N-ts1

      (Presente et al., 2001)

      NΔEGF1-18.hs fails to rescue N264-47

      (Lieber et al., 1993)
      Comments

      NΔEGF1-18.hs fails to rescue the long term memory defects in Nl1N-ts1 animals.

      (Presente et al., 2004)

      Unable to rescue the cuticle phenotype of N264-47 embryos.

      (Lieber et al., 1993)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      NΔ1-18
      (Powell et al., 2001)
      NΔEGF1-18.hs
      ΔEGF1-18
      (Lieber et al., 1993)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)