FB2026_02 , released June 18, 2026
Allele: Dmel\MetD29
Open Close
General Information
Symbol
Dmel\MetD29
Species
D. melanogaster
Name
FlyBase ID
FBal0033992
Feature type
allele
Associated gene
Dmel\Met
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Wilson, 1996)
Mutagen
X ray
(Ashok et al., 1998, Wilson, 1996, Turner and Wilson, 1995)
gamma ray
(Minkoff and Wilson, 1992)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Rst(1)JHD29/Y hemizygotes show good levels of survival.

      (Wilson et al., 2006)

      Heterozygous and Rst(1)JHD29/Rst(1)JH1 larvae show increased resistance to Methoprene compared to wild-type. Rst(1)JHD29/Rst(1)JH1 adults derived from larvae treated with Methoprene have normal bristle patterns on sternites 6 and 7, in contrast to wild-type adults derived from larvae treated with Methoprene, which have disrupted bristle patterns on these sternites.

      (Wilson, 1996)

      Flies carrying Rst(1)JHD29 have a competitive disadvantage compared to wild-type flies.

      (Minkoff and Wilson, 1992)

      like Rst(1)JH1

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      MetD29/MetD29 is an enhancer of ovary phenotype of br1

      (Wilson et al., 2006)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      br1, Rst(1)JHD29 double mutant escapers show significantly reduced levels of oogenesis compared to br1 single mutants.

      (Wilson et al., 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Tom Wilson.

      Comments
      Comments

      The fitness component(s) responsible for the competitive disadvantage of flies carrying mutant alleles of Rst(1)JH have been analysed in Rst(1)JH1, Rst(1)JH2, Rst(1)JH3, Rst(1)JHD29 and Rst(1)JHN6 flies. Small but significant differences were found between the pooled Rst(1)JH alleles and wild-type for pupal developmental time, pupal mortality, and early adult fecundity. These differences results in a large competitive disadvantage.

      (Minkoff and Wilson, 1992)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      MetD29
      (Wilson et al., 2006, Beno et al., 2005, Flatt and Kawecki, 2004, Wilson, 1996, Turner and Wilson, 1995)
      Rst(1)JHD29
      Name Synonyms
      Secondary FlyBase IDs
        References (7)