FlyBase Allele Report: Dmel\eas[hs.PP]

General Information

Symbol

Dmel\eas^hs.PP

Species

D. melanogaster

Name

heat shock construct of Pavlidis

FlyBase ID

FBal0034454

Feature type

allele

Associated gene

Dmel\eas

Associated Insertion(s)

Carried in Construct

P{hs-eas.c12}

Key Links

Transgenic product class

cDNA

(Pavlidis et al., 1994)

wild_type

(Pavlidis et al., 1994)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Pavlidis et al., 1994)

wild_type

(Pavlidis et al., 1994)

Mutagen

in vitro construct

(Pavlidis et al., 1994)

Progenitor genotype

Carried in construct

P{hs-eas.c12}

Cytology

Description

Construct: cDNA 12 of the eas gene expressed from a heat inducible promoter.

(Pavlidis et al., 1994)

Allele components

Component

Use(s)

Encoded product / tool

eas

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

wild-type

(Pavlidis et al., 1994)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

eas^hs.PP rescues eas²

(Pavlidis et al., 1994)

Partially rescues

eas^hs.PP partially rescues eas^alaE13

(Pascual et al., 2005)

Fails to rescue

eas^hs.PP fails to rescue eas^P372

(Pavlidis et al., 1994)

Comments

Expression of eas^hs.PP can almost completely rescue the mushroom body phenotype of eas^alaE13/Y flies if initiated on the first day of the third-larval stage. If expression is initiated in the late third-instar stage, rescue is partial and later induction of fails to rescue the phenotype at all.

(Pascual et al., 2005)

Heat shock at 37^oC for 2 hrs on 3 successive days rescues the mutant phenotype of eas², but not the lethality of the eas^P372 chromosome.

(Pavlidis et al., 1994)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

eas^hs.PP

Name Synonyms

heat shock construct of Pavlidis

(Pavlidis et al., 1994)

Secondary FlyBase IDs

References (3)

Report Sections

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