Nucleotide substitution: G?A. Contain a 5'-splice junction which has been altered from GTttGT to GTttaT. Also contains a 9nt deletion that changes the prredicted peptide sequence in a putative membrane-spanning segment from SDTAVTLLFTAE to SDTVLFTAE.
Mutants are noticeably smaller than wild-type but not obviously sick or deformed. The majority of homozygous mutants that have been entrained to diurnal lighting (LD, 12hr light:12ht dark) and subsequently monitored under constant darkness (DD) are arrhythmic - only a small number are strongly rhythmic. In contrast to wild-type however, under LD entrainment however mutants exhibit most activity at night.
Show saccadic walking behavior in the absence of anaesthetics as nahar38, and abdominal morphology like nahar38. Response to enflurane and isoflurane is indistinguishable from wild type. Mosaic analysis reveals that the focus for anesthetic resistance maps close to the focus for the geotaxis defect, in the head, mapping back to the cephalic region in the blastoderm.
Homozygotes show resistance to halothane in an inebriometer assay (an assay of geotactic and postural behaviour) compared to wild-type flies.
Individuals are able to remain standing upright in the presense of halothane.
In the absence of anaesthetics flies show several mutant phenotypes. Fewer offspring are produced compared to wild type. Abdomens are more slender and elongated than wild type. Flies show hesitancy when walking, mechanical shock enhances the hesitancy. When exposed to anaesthetics individuals become immobile, they freeze, and then fall over.
Alleles of na form a phenotypic series, going from strongest to weakest: nahar38 > nahar85 > naP890 > na1 > naPex1 > naPex2.