FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Ada32
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General Information
Symbol
Dmel\Ada32
Species
D. melanogaster
Name
FlyBase ID
FBal0034849
Feature type
allele
Associated gene
Dmel\Ada3
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
X ray
(de la Pompa, 1994, Ferrus et al., 1990)
Progenitor genotype
Cytology
Description

The dik protein truncates at amino acid 256.

(Grau et al., 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The wing discs in homozygous dik2 third instar larvae are small compared to controls.

      dik2 mutant cells are not recovered in germline clones, while twin control cell are recovered. No egg-producing ovarioles are recovered.

      (Grau et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      Ada32, Df(3L)iro-2 has scutellum | heat sensitive phenotype, suppressible by araUAS.cGa/Scer\GAL4salm-AC216

      (Grau et al., 2008)
      Other
      Statement
      Reference

      Ada32, Df(3L)iro-2 has scutellum | heat sensitive phenotype

      (Grau et al., 2008)

      Ada32, Df(3L)iro-DFM1 has scutellum | heat sensitive phenotype

      (Grau et al., 2008)

      Ada32, Df(3L)iro-DFM3 has scutellum | heat sensitive phenotype

      (Grau et al., 2008)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      80% of dik2 Df(3L)iro-2 double heterozygotes (dik2/+; Df(3L)iro-2/+ for females and dik2; Df(3L)iro-2/dik+tE4RX for males) display a phenotype that is characteristic of loss of the Iroquoi gene complex (IRO-C), which in around half of mutants appears as loss of the scutellum and several bristles from the remaining scutum in the thorax. The penetrance and expressivity of this phenotype are temperature sensitive, appearing stronger at 27[o]C than at 17[o]C. A similar phenotype is seen in flies heterozygous for dik2 and either Df(3L)iro-DFM1 or Df(3L)iro-DFM3.

      Expression of araScer\UAS.cGa under the control of Scer\GAL4salm-AC216 completely suppresses the IRO-C phenotypes seen in dik2/+; Df(3L)iro-2/+ mutant flies.

      (Grau et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Mutation in the haplo-lethal (HL) region of the Sh complex.

      (Ferrus et al., 1990)

      Mutation within the haplo-lethal (HL) region of the Sh complex.

      (de la Pompa, 1994)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Ada32
      dAda32
      (Grau et al., 2008)
      dik2
      l(1)16Fh7688
      Name Synonyms
      Secondary FlyBase IDs
        References (4)