FlyBase Allele Report: Dmel\rl[D334N.hs.sev]

General Information

Symbol

Dmel\rl^D334N.hs.sev

Species

D. melanogaster

Name

FlyBase ID

FBal0035510

Feature type

allele

Associated gene

Dmel\rl

Associated Insertion(s)

Carried in Construct

P{sE-rl^D334N}

Key Links

Transgenic product class

missense_variant

(Brunner et al., 1994)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Brunner et al., 1994)

Mutagen

in vitro construct

(Brunner et al., 1994)

Progenitor genotype

Carried in construct

P{sE-rl^D334N}

Cytology

Description

An Hsp70 promoter in conjunction with a duplicated sev enhancer drives expression of a mutated form of rl that carries a D334N amino acid replacement.

(Brunner et al., 1994)

Allele components

Component

Use(s)

Regulatory region(s)

Hsp70

sev

Encoded product / tool

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible

(Smith et al., 2002, van der Straten et al., 1997)

Phenotype Manifest In

eye

(van der Straten et al., 1997, Brunner et al., 1994)

ommatidium

(Zhang and Lu, 2000)

photoreceptor cell R7

(Dickson et al., 1995, Brunner et al., 1994)

photoreceptor cell R7 | ectopic

(Smith et al., 2002, Zhang and Lu, 2000)

photoreceptor cell R7 | increased number

(Wittwer et al., 2001)

Detailed Description

Statement

Reference

Flies carrying rl^D334N.hs.sev have an average of 1.6 ectopic R7 cells per ommatidium.

(Smith et al., 2002)

Flies carrying rl^D334N.hs.sev have ectopic R7 cells in the eye (with an average of 2.7 R7 cells per ommatidium).

(Wittwer et al., 2001)

In the eyes of rl^D334N.hs.sev/+ flies, 22% of the ommatidia contain two or three R7 cells.

(Zhang and Lu, 2000)

Rough eye phenotype is not suppressed by mutations of Hsp83.

(van der Straten et al., 1997)

The formation of additional R7 cells requires phyl⁺.

(Dickson et al., 1995)

Rough eyes, with multiple R7 cells per ommatidium.

(Brunner et al., 1994)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

rl^D334N.hs.sev has visible phenotype, suppressible by mask[+]/mask^10.22

(Smith et al., 2002)

Phenotype Manifest In

Suppressed by

Statement

Reference

rl^D334N.hs.sev has photoreceptor cell R7 | ectopic phenotype, suppressible by mask[+]/mask^10.22

(Smith et al., 2002)

rl^D334N.hs.sev has photoreceptor cell R7 | increased number phenotype, suppressible by lilli^3E8

(Wittwer et al., 2001)

rl^D334N.hs.sev has photoreceptor cell R7 | ectopic phenotype, suppressible by cnk^X-10/cnk^sag13L

(Zhang and Lu, 2000)

rl^D334N.hs.sev has ommatidium phenotype, suppressible by cnk^X-10/cnk^sag13L

(Zhang and Lu, 2000)

Suppressor of

Statement

Reference

rl^D334N.hs.sev is a suppressor of photoreceptor cell R7 | ectopic phenotype of cnk^X-10/cnk^sag13L

(Zhang and Lu, 2000)

Additional Comments

Genetic Interactions

Statement

Reference

The rl^D334N.hs.sev ectopic R7 cell phenotype is partially suppressed by mask^10.22/+; the double mutant flies have an average of 1.2 ectopic R7 cells per ommatidium.

(Smith et al., 2002)

The formation of multiple R7 cells in flies carrying rl^D334N.hs.sev is suppressed in a lilli^3E8 clone.

(Wittwer et al., 2001)

In sag^X-10/sag^13L; rl^D334N.hs.sev flies, 99% of ommatidia contain one R7 cell.

(Zhang and Lu, 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

rl^D334N.hs.sev

rl^DN

(van der Straten et al., 1997)

rl^SEM

(Smith et al., 2002)

sE-rl^DN

(Dickson et al., 1995)

sev-rl^SEM

(Zhang and Lu, 2000)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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