FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\sisA+t12
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General Information
Symbol
Dmel\sisA+t12
Species
D. melanogaster
Name
FlyBase ID
FBal0035615
Feature type
allele
Associated gene
Dmel\sisA
Associated Insertion(s)
Carried in Construct
P{sisA1}
Key Links
Genomic Maps

Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Erickson and Cline, 1993)
Progenitor genotype
Carried in construct
P{sisA1}
Cytology
Description

Contained within a 12kb genomic NotI-Sau3A fragment.

(Erickson and Cline, 1993)
Allele components
Component
Use(s)
Regulatory region(s)
sisA
Encoded product / tool
sisA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
rescue_region
X:11,318,045..11,330,045 [-]
Linked to:
NotI-END restriction fragment
Comment:

Position of restriction fragment on reference sequence inferred by FlyBase curator based on author statement. Position of downstream rescue fragment breakpoint is approximate due to use of Sau3A partial digest phage lambda library. Rescue fragment reported to be 12kb.

(Erickson and Cline, 1993)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Males carrying two copies of sisA+t12 in a wild-type background show approximately 50% viability.

      (Sefton et al., 2000)

      Fully complements the sisA1 mutation.

      (Erickson and Cline, 1993)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The viability of males carrying two copies of sisA+t12 is further reduced if they are also carrying ost10. This interaction is dose sensitive; two copies of ost10 reduce viability more than one copy. Addition of two copies of sisA+t12 and two copies of ost10 has no effect on the viability of Sxlf1/Y males.

      (Sefton et al., 2000)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      sisA+t12
      Name Synonyms
      Secondary FlyBase IDs
        References (3)