FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\spzD1-RPQ
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General Information
Symbol
Dmel\spzD1-RPQ
Species
D. melanogaster
Name
FlyBase ID
FBal0035690
Feature type
allele
Associated gene
Dmel\spz
Associated Insertion(s)
Carried in Construct
Also Known As
spzD1RPQ
Key Links
Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Morisato and Anderson, 1994)
Mutagen
PM hybrid dysgenesis
(Morisato and Anderson, 1994)
Progenitor genotype
spzD1
(Morisato and Anderson, 1994)
Cytology
Description

Break maps to a 0.8kb XhoI-BglII fragment in the spz region.

(Morisato and Anderson, 1994)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous and spzD1-RPQ/spz4 larvae have significantly higher levels of muscle defects than wild-type larvae.

      (Halfon and Keshishian, 1998)

      Affected embryos are dorsalized.

      (Morisato and Anderson, 1994)

      Mutant embryos respond to injected purified polarizing activity (spz), but lack polarizing activity themselves.

      (Schneider et al., 1994)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The ventralized phenotype that causes the failure of cuticle differentiation in embryos from Spn27A1/Df(2L)BSC7 mothers is abolished when mothers also have the mutant genotype spzD1-RPQ/Df(3R)Tl-D. Such embryos have a dorsalized phenotype that is indistinguishable from those produced by single mutant spzD1-RPQ/Df(3R)Tl-D mothers.

      (Hashimoto et al., 2003)

      Perivitelline fluid from embryos laid by spzD1-RPQ/Df(3R)Bd females does not show axis-inducing activity when injected into the perivitelline space of embryos derived from pip1/pip2 females.

      (Chang and Morisato, 2002)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      No P element detected at spz.

      (Morisato and Anderson, 1994)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      spzD1-RPQ
      spzD1RPQ
      (Halfon and Keshishian, 1998, Schneider et al., 1994)
      spzRPQ
      (Morisato, 2001)
      Name Synonyms
      Secondary FlyBase IDs
        References (7)