FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ttk69.hs
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General Information
Symbol
Dmel\ttk69.hs
Species
D. melanogaster
Name
FlyBase ID
FBal0035856
Feature type
allele
Associated gene
Dmel\ttk
Associated Insertion(s)
Carried in Construct
P{hs69-ttk}
Also Known As
hs-ttk69
Key Links
Transgenic product class
wild_type
(Read et al., 1992)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Read et al., 1992)
Mutagen
in vitro construct
(Guo et al., 1995, Read et al., 1992)
Progenitor genotype
Carried in construct
P{hs69-ttk}
Cytology
Description

ttk 3.2 transcript encoding the 69kD protein is under the control of a Hsp70 promoter.

(Read et al., 1992)
Allele components
Component
Use(s)
Regulatory region(s)
Hsp70
Encoded product / tool
ttk
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Embryos heat shocked at 5-6 hours of development do not complete germ band retraction. Embryos exhibit an almost complete loss of neurons.

      (Vervoort et al., 1997)

      Overexpression of ttk at 6-5 to 8.5 hours of embryonic development causes significant reduction in the number of peripheral neurons. Scolopale cells are transformed to cap cells and external sensory organs are transformed to support cells. Overexpression in the adult results in duplicated bristles and multiple sockets.

      (Guo et al., 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      ttk69.hs is a suppressor of wing margin bristle | ectopic phenotype of acHw-49c

      (Badenhorst et al., 2002)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The addition of ttk69.hs/+ to acHw-49c/+ animals leads to slight suppression of the ectopic wing margin bristle phenotype (80% of the bristles).

      (Badenhorst et al., 2002)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      ttk69.hs
      Name Synonyms
      Secondary FlyBase IDs
        References (5)