FlyBase Allele Report: Dmel\rho[Mod]

General Information

Symbol

Dmel\rho^Mod

Species

D. melanogaster

Name

Moderate

FlyBase ID

FBal0035903

Feature type

allele

Associated gene

Dmel\rho

Associated Insertion(s)

P{HS-rho}Mod

Carried in Construct

Also Known As

rho^HS-mod

Key Links

Allele class

gain of function allele

Mutagen

P-element activity

Nature of the Allele

Allele class

gain of function allele

(Sturtevant and Bier, 1995, Sturtevant et al., 1993)

Mutagen

P-element activity

(Sturtevant et al., 1993)

Progenitor genotype

rho^hs.PSt

(Sturtevant et al., 1993)

Associated Insertion(s)

P{HS-rho}Mod

Cytology

Description

rho gene expression is driven by an Hsp70 promoter.

(Sturtevant et al., 1993)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible

(Guichard et al., 1999, Biehs et al., 1998)

visible | dominant

(Sturtevant et al., 1993)

Phenotype Manifest In

wing

(Guichard et al., 1999, Biehs et al., 1998)

wing vein

(Yu et al., 1996, Sturtevant et al., 1993)

wing vein | ectopic

(Biehs et al., 1998, Yu et al., 1996)

wing vein L3

(Yu et al., 1996)

wing vein L4

(Yu et al., 1996)

Detailed Description

Statement

Reference

Homozygous insertions cause a moderate extra-vein phenotype at 25^oC.

(Guichard et al., 1999)

Flies carrying rho^Mod have ectopic wing vein material.

(Biehs et al., 1998)

One copy causes a short ectopic segment of vein between wing veins L3 and L4 near the margin and slight L3 and L4 deltas.

(Yu et al., 1996)

In the absence of heat induction individuals display a moderate constitutive excess vein phenotype. Homozygous phenotype is strongly suppressed by heterozygous rho^ve-1.

(Sturtevant et al., 1993)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

rho^Mod has wing vein | ectopic phenotype, enhanceable by sog⁶

(Yu et al., 1996)

NOT Enhanced by

Statement

Reference

rho^Mod has phenotype, non-enhanceable by btl::Egfr^Mod

(Guichard et al., 1999)

NOT Enhancer of

Statement

Reference

rho^Mod is a non-enhancer of phenotype of btl::Egfr^Mod

(Guichard et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

rho^Mod/+; btl::Egfr^Mod/+ double heterozygotes show no enhancement of the extra vein phenotype.

(Guichard et al., 1999)

sog⁶ and an extra copy of dpp⁺ strongly enhances the rho^Mod extra wing vein phenotype, extra vein material running parallel to wing vein L2 and L5.

(Yu et al., 1996)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Phenotype dependent on site of insertion of P{HS-rho} into the genome.

(Sturtevant et al., 1993)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

rho^HS-Mod

(Biehs et al., 1998, Yu et al., 1996, Sturtevant and Bier, 1995)

rho^HS-mod

(Guichard et al., 1999)

rho^Mod

ve^Mod

Name Synonyms

Moderate

(Sturtevant et al., 1993)

Secondary FlyBase IDs

References (5)

Report Sections

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