FlyBase Allele Report: Dmel\Mhc[19]

General Information

Symbol

Dmel\Mhc¹⁹

Species

D. melanogaster

Name

FlyBase ID

FBal0038910

Feature type

allele

Associated gene

Dmel\Mhc

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Kronert et al., 1995)

Progenitor genotype

Cytology

Description

Amino acid replacement: E?K.

(Kronert et al., 1995)

The mutation falls in the 16th exon. The same mutation is found in Mhc¹³.

(Kronert et al., 1995)

Nucleotide substitution: G?A.

(Kronert et al., 1995)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2L:16,785,602..16,785,602 [+]

Nucleotide change:

G16785602A

Reported nucleotide change:

G?A

Amino acid change:

Reported amino acid change:

E?K

(Kronert et al., 1995)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

flightless | dominant

(Kronert et al., 1995, Cripps et al., 1994)

viable

(Kronert et al., 1995)

Phenotype Manifest In

indirect flight muscle cell

(Kronert et al., 1995)

muscle cell of dorsal longitudinal indirect flight muscle 45a

(Cripps et al., 1994)

muscle cell of dorsal longitudinal indirect flight muscle 45b

(Cripps et al., 1994)

muscle cell of dorsal longitudinal indirect flight muscle 45c

(Cripps et al., 1994)

muscle cell of dorsal longitudinal indirect flight muscle 45d

(Cripps et al., 1994)

muscle cell of dorsal longitudinal indirect flight muscle 45e

(Cripps et al., 1994)

muscle cell of dorsal longitudinal indirect flight muscle 45f

(Cripps et al., 1994)

Detailed Description

Statement

Reference

Myofibres of the indirect flight muscles of homozygous or Mhc¹⁹/Mhc¹ flies (but not of heterozygous flies) often appear bunched at one attachment site, although the myofibre surface does remain attached at both attachment sites. This phenotype develops as the fly ages, with the myofibres appearing normal immediately after eclosion.

(Kronert et al., 1995)

Reduced viability when heterozygous with Df(2L)H20 or Mhc¹. Heterozygotes with Mhc¹ display a distinct alteration in the shape of the dorso-longitudinal muscles (DLM), the greater part of the muscle mass has 'contracted' toward the anterior thoracic attachment site.

(Cripps et al., 1994)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Not rescued by

Mhc¹⁹ is not rescued by Mhc^+t41.9

(Kronert et al., 1995)

Comments

The dominant flightless phenotype is not rescued by Mhc^+t41.9.

(Kronert et al., 1995)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Mhc¹⁹

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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