FlyBase Allele Report: Dmel\Su(H)[hs.PS]

General Information

Symbol

Dmel\Su(H)^hs.PS

Species

D. melanogaster

Name

heat shock construct of Schweisguth

FlyBase ID

FBal0039062

Feature type

allele

Associated gene

Dmel\Su(H)

Associated Insertion(s)

Carried in Construct

P{Hs-Su(H)}

Key Links

Transgenic product class

cDNA

(Schweisguth and Posakony, 1994)

wild_type

(Schweisguth and Posakony, 1994)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Schweisguth and Posakony, 1994)

wild_type

(Schweisguth and Posakony, 1994)

Mutagen

in vitro construct

(Schweisguth and Posakony, 1994)

Progenitor genotype

Carried in construct

P{Hs-Su(H)}

Cytology

Description

Full length Su(H) cDNA under the control of an Hsp70 promoter.

(Schweisguth and Posakony, 1994)

Allele components

Component

Use(s)

Regulatory region(s)

Hsp70

Encoded product / tool

Su(H)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal memory | adult stage

(Song et al., 2009)

Phenotype Manifest In

macrochaeta

(Schweisguth and Posakony, 1994)

microchaeta

(Morel et al., 2001, Schweisguth and Posakony, 1994)

Detailed Description

Statement

Reference

Flies given a 30 minute heat shock followed by a 3 hour rest have a lower 24 hour memory compared to wild type.

(Song et al., 2009)

Expression of Su(H)^hs.PS under mild heat shock conditions produces adult flies that have a weakly decreased bristle density in the dorsal thorax.

(Morel et al., 2001)

Does not cause sensory cell glial cell transformation caused by N^{int.SH.Scer\UAS}.

(van de Bor and Giangrande, 2001)

With a heat shock regime of 3x60 minutes at 37^oC separated by two intervals of 90mins at 25^oC, at 16, 20 or 24 hrs APF, the phenotype is very similar to the H double socket phenotype at most notum microchaetae and macrochaetae positions. Earlier, shorter heat shocks result in loss of nearly all notum microchaetae.

(Schweisguth and Posakony, 1994)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

H^hs.PB, Su(H)^hs.PS has increased cell number | adult stage phenotype

(Morel et al., 2001)

Phenotype Manifest In

Suppressed by

Statement

Reference

Su(H)^hs.PS has microchaeta phenotype, suppressible by H^C6.hs

(Morel et al., 2001)

Enhancer of

Statement

Reference

Su(H)^hs.PS is an enhancer of microchaeta phenotype of H^hs.PB

(Morel et al., 2001)

NOT Enhancer of

Statement

Reference

Su(H)^hs.PS is a non-enhancer of phenotype of H^C6.hs

(Morel et al., 2001)

Suppressor of

Statement

Reference

Su(H)^hs.PS is a suppressor of phenotype of N^l1N-ts1

(Schweisguth et al., 1996)

Other

Statement

Reference

H^hs.PB, Su(H)^hs.PS has thorax | adult stage phenotype

(Morel et al., 2001)

Additional Comments

Genetic Interactions

Statement

Reference

When Su(H)^hs.PS is added to H^hs.PB flies an extreme overproliferation of bristles is seen on the thorax.

(Morel et al., 2001)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Su(H)^hs.PS rescues Su(H)⁸

(Song et al., 2009)

Comments

Expression of Su(H)^hs.PS with 30 minutes heat shock at 37C rescues the reduced 24 hour memory phenotype seen in Su(H)⁸ homozygotes.

(Song et al., 2009)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Su(H)^hs.PS

Name Synonyms

heat shock construct of Schweisguth

(Schweisguth and Posakony, 1994)

Secondary FlyBase IDs

References (6)

Report Sections

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