Open Close
General Information
Symbol
Dmel\UbxIa.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0039098
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-Ubx
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

Ubx form Ia cDNA expressed under influence of UASt regulatory sequences.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In

embryonic abdominal segment 1 & abdominal ventral oblique muscle 6 | ectopic, with Scer\GAL4how-24B

embryonic abdominal segment 1 & abdominal ventral transverse muscle 1 | ectopic, with Scer\GAL4how-24B

embryonic thoracic segment & ventral longitudinal muscle, with Scer\GAL4how-24B

thoracic segment & abdominal ventral acute muscle 1 | precursor | ectopic, with Scer\GAL4how-24B

Detailed Description
Statement
Reference

Scer\GAL4how-24B-mediated expression of UbxIa.Scer\UAS results in an ectopic DA3 muscle in thoracic segment 1. The number of nuclei in this ectopic muscle is identical to that in wild type abdominal segments.

Expression of UbxIa.Scer\UAS using Scer\GAL4kirre-rP298, but not Scer\GAL4sns.PK, converts the number of nuclei in thoracic segments 2 and 3 to that found in abdominal segments.

85% of the embryonic/first instar larval cuticles of UbxIa.Scer\UAS; Scer\GAL4arm.PS animals lack Keilin's organs.

Scer\GAL4444-mediated expression at 17oC causes the thoracic and some head segments of first instar larvae to display A1 identity. At 29oC larvae develop all segments anterior to A2 with an A3-A5 pattern.

When expressed via Scer\GAL41151, T2 myoblast migration during pupal development is unaffected. The indirect flight muscle fail to complete development and eventually degenerate.

Scer\GAL4E132 induced expression in the eye-antennal disc causes transformation of the antenna into leg. Scer\GAL4Bx-MS1096 or Scer\GAL4C-765 induced expression in the wing disc causes transformation of the wing into haltere-like tissue. Co-expression of P{UAS-exd.G} (induced by Scer\GAL4Bx-MS1096) does not significantly modify the wing transformation. Scer\GAL4C-765 induced expression also transforms the mesonotum into the homologous region of the third thoracic segment. Scer\GAL4c739 and Scer\GAL4C-765 induced expression in the abdomen fails to cause segmental change. Ubxabx-1 Ubxbx-3 Ubxpbx-1/Ubxlac1 combination transforms the metathorax into mesothorax (including transformation of halteres into wings), Scer\GAL4Bx-MS1096 induced expression allows full rescue.

When expressed via Scer\GAL4how-24B in embryos, an ectopic precursor for abdominal muscle 26 appears in the ventral region of T1-T3. Ventral longitudinal muscles of thoracic segments assume the identity of the abdominal segments. Abdominal segment 1 gains two muscles that it normally lacks: external ventral oblique muscles 17 and 25. Insertion sites of transformed muscles are sometimes aberrant. The thoracic cuticle remains unaffected. Both gastric caeca and the first midgut constriction are missing.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Phenotype can be partially reverted by adding an additional dose of exd+.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Expression dependent on Scer\GAL4.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
UbxIa.Scer\UAS
UbxIa.UAS
Name Synonyms
Secondary FlyBase IDs
    References (14)