FB2026_03 , released September 17, 2026
Allele: Dmel\btl::tort4021b.hs.sev
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General Information
Symbol
Dmel\btl::tort4021b.hs.sev
Species
D. melanogaster
Name
FlyBase ID
FBal0039188
Feature type
allele
Associated gene
btl::tor
Associated Insertion(s)
Carried in Construct
P{sE-tor4021-btl}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Sutherland et al., 1996, Reichman-Fried et al., 1994)
Progenitor genotype
Carried in construct
P{sE-tor4021-btl}
Cytology
Description

Transmembrane and extracellular domain of tor13D are fused to the tyrosine kinase domain of btl, expression of the chimera is driven by an Hsp70 promoter and a single copy of the 1.2kb sev enhancer.

(Reichman-Fried et al., 1994)
Allele components
Component
Use(s)
Regulatory region(s)
Hsp70
sev
Encoded product / tool
btl::tor
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Tracheal migration in wild type embryos is unaffected by the constitutively active btl::tort4021b.hs.sev protein, tracheal migration defects in btl homozygous embryos are partially rescued.

      (Reichman-Fried et al., 1994)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      btl::tort4021b.hs.sev is a suppressor of larval tracheal system phenotype of bnl00857

      (Sutherland et al., 1996)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      A constitutively activated form of the btl receptor (btl::tort4021b.hs.sev) can partially ameliorate the effect of absence of bnl; modest restoration of branching in bnl00857 embryos.

      (Sutherland et al., 1996)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      btl::tort4021b.hs.sev
      btl::tort4021b.hs
      tor-DFGF-R1
      (Reichman-Fried et al., 1994)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)