FlyBase Allele Report: Dmel\emc[ip15]

General Information

Symbol

Dmel\emc^ip15

Species

D. melanogaster

Name

FlyBase ID

FBal0039315

Feature type

allele

Associated gene

Dmel\emc

Associated Insertion(s)

P{}emc^ip15

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

P-element activity

(Cubas et al., 1994)

Delta2-3 transposase

(Heitzler et al., 1996)

Progenitor genotype

Associated Insertion(s)

P{}emc^ip15

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | embryonic stage

(Cubas et al., 1994)

decreased cell number | embryonic stage

(Cubas et al., 1994)

lethal

(Heitzler et al., 1996)

Phenotype Manifest In

axon | embryonic stage

(Cubas et al., 1994)

denticle row 1 & abdominal 1 ventral denticle belt

(Cubas et al., 1994)

denticle row 1 & abdominal 2 ventral denticle belt

(Cubas et al., 1994)

denticle row 1 & abdominal 3 ventral denticle belt

(Cubas et al., 1994)

denticle row 1 & abdominal 4 ventral denticle belt

(Cubas et al., 1994)

denticle row 1 & abdominal 5 ventral denticle belt

(Cubas et al., 1994)

denticle row 1 & abdominal 6 ventral denticle belt

(Cubas et al., 1994)

denticle row 1 & abdominal 7 ventral denticle belt

(Cubas et al., 1994)

denticle row 2 & abdominal 1 ventral denticle belt

(Cubas et al., 1994)

denticle row 2 & abdominal 2 ventral denticle belt

(Cubas et al., 1994)

denticle row 2 & abdominal 3 ventral denticle belt

(Cubas et al., 1994)

denticle row 2 & abdominal 4 ventral denticle belt

(Cubas et al., 1994)

denticle row 2 & abdominal 5 ventral denticle belt

(Cubas et al., 1994)

denticle row 2 & abdominal 6 ventral denticle belt

(Cubas et al., 1994)

denticle row 2 & abdominal 7 ventral denticle belt

(Cubas et al., 1994)

embryonic/larval spiracle | embryonic stage

(Cubas et al., 1994)

embryonic head

(Cubas et al., 1994)

embryonic midgut constriction 1

(Cubas et al., 1994)

embryonic midgut constriction 2

(Cubas et al., 1994)

embryonic midgut constriction 3

(Cubas et al., 1994)

endoderm

(Cubas et al., 1994)

external sensory organ

(Cubas et al., 1994)

filzkorper | embryonic stage

(Cubas et al., 1994)

larval longitudinal connective

(Cubas et al., 1994)

larval somatic muscle cell

(Cubas et al., 1994)

Malpighian tubule

(Cubas et al., 1994)

Malpighian tubule tip cell

(Cubas et al., 1994)

mandibular segment | embryonic stage

(Cubas et al., 1994)

ventral denticle belt

(Cubas et al., 1994)

visceral trunk mesoderm

(Cubas et al., 1994)

Detailed Description

Statement

Reference

emc^ip15/Df(3L)emc-E12 embryos show mutant phenotypes in tissues of all three germ layers. Head involution fails and differentiation of the mandibular apparatus, spiracles and filzkorper was incomplete. Denticles of first and second row are missing, indicating a faulty specification of the intersegmental border cells. 50% of embryos show subtle deviations of axonal pathways or localized defects in the longitudinal connectives. In the PNS, a few neurons are missing, and there are rare changes in neuronal identity and disorganization of neuronal groups and axonal routing. Developing Malpighian tubules have extra tip cells, which do not enhance proliferation, and elongation does not occur. Somatic muscles are missing or deranged, with many detached from the epidermis. Distribution of visceral mesoderm over the developing midgut is abnormal. Midgut constrictions do not form, and midgut epithelium is irregular in thickness.

(Cubas et al., 1994)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Other

Statement

Reference

emc^ip15, ttk[+]/ttk^rM730 has wing margin bristle | ectopic phenotype

(Badenhorst et al., 2002)

emc^ip15, ttk^rM730 has wing margin bristle | ectopic phenotype

(Badenhorst et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

The addition of ttk^rM730/+ or Df(3R)awd-KRB to emc^ip15/+ animals leads to a weak ectopic wing margin bristle phenotype.

(Badenhorst et al., 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

P. Heitzler.

(Cubas et al., 1994)

Comments

Phenotypes of emc alleles can be ordered, going from weakest to strongest: emc¹ < emc¹/Df(3L)emc-E12 < emc⁹ = emc^ip15 = emc⁹/emc^ip15 < emc⁹/Df(3L)emc-E12 = emc^ip15/Df(3L)emc-E12 < Df(3L)emc-E12/Df(3L)emc-E12.

(Cubas et al., 1994)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

emc^IP15

(Badenhorst et al., 2002)

emc^ip15

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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