FB2026_02 , released June 18, 2026
Allele: Dmel\l(3)Lak4
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General Information
Symbol
Dmel\l(3)Lak4
Species
D. melanogaster
Name
FlyBase ID
FBal0039584
Feature type
allele
Associated gene
l(3)Lak
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
    Nature of the Allele
    Allele class

    hypomorphic allele - genetic evidence

    (Cripps et al., 1994)
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Heterozygotes display abnormal indirect flight muscle (IFM) myofibrils, frequent aberrations in Z-disc shape and Z-discs that do not span the myofibril. Transverse sections of muscles show the periphery of the thick and thin filament lattice is disorganised. Dominant flightlessness is rescued by Ts(YSt;3Lt)A158, but is not reduced or rescued by Ts(YSt;3Lt)D8. Heteroallelic combinations of l(3)Lak are embryonic lethal. Unhatched eggs contain fully formed, phenotypically normal larvae that move very slowly due to muscle dysfunction. Newly hatched larvae and those removed from the vitelline membrane moved slowly but within a few hours died with a 'collapsed' phenotype, possibly due to the inability to feed. Larval muscles display only areas of thick and thin filament interdigitation, filament orientations are often disorganised and Z-discs are irregular in appearance. Heteroallelic lethality can be rescued by Ts(YSt;3Lt)A158, but not by Ts(YSt;3Lt)D8.

        (Cripps et al., 1994)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        l(3)Lak4
        Name Synonyms
        Secondary FlyBase IDs
          References (1)