FlyBase Allele Report: Dmel\lola[2B13]

FB2026_02 , released June 18, 2026

FB2026_02 , released June 18, 2026

Allele: Dmel\lola^2B13

General Information

Symbol

Dmel\lola^2B13

Species

D. melanogaster

Name

FlyBase ID

FBal0039614

Feature type

allele

Associated gene

Associated Insertion(s)

P{lacW}lola^2B13

Carried in Construct

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Giniger et al., 1994)

Progenitor genotype

Associated Insertion(s)

P{lacW}lola^2B13

Cytology

Description

Allele components

Component

Use(s)

Inserted element

Encoded product / tool

reporter enzyme

Tagged with

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Giniger et al., 1994)

Phenotype Manifest In

abdominal 1 lateral monoscolopidial chordotonal organ lch1

(Giniger et al., 1994)

abdominal 1 lateral pentascolopidial chordotonal organ lch5

(Giniger et al., 1994)

abdominal 2 lateral monoscolopidial chordotonal organ lch1

(Giniger et al., 1994)

abdominal 2 lateral pentascolopidial chordotonal organ lch5

(Giniger et al., 1994)

abdominal 3 lateral monoscolopidial chordotonal organ lch1

(Giniger et al., 1994)

abdominal 3 lateral pentascolopidial chordotonal organ lch5

(Giniger et al., 1994)

abdominal 4 lateral monoscolopidial chordotonal organ lch1

(Giniger et al., 1994)

abdominal 4 lateral pentascolopidial chordotonal organ lch5

(Giniger et al., 1994)

abdominal 5 lateral monoscolopidial chordotonal organ lch1

(Giniger et al., 1994)

abdominal 5 lateral pentascolopidial chordotonal organ lch5

(Giniger et al., 1994)

abdominal 6 lateral monoscolopidial chordotonal organ lch1

(Giniger et al., 1994)

abdominal 6 lateral pentascolopidial chordotonal organ lch5

(Giniger et al., 1994)

abdominal 7 lateral monoscolopidial chordotonal organ lch1

(Giniger et al., 1994)

abdominal 7 lateral pentascolopidial chordotonal organ lch5

(Giniger et al., 1994)

larval abdominal intersegmental nerve

(Giniger et al., 1994)

larval longitudinal connective

(Giniger et al., 1994)

larval VUM neuron

(Giniger et al., 1994)

symmetrical commissure

(Giniger et al., 1994)

VUM4 interneuron

(Giniger et al., 1994)

VUM5 interneuron

(Giniger et al., 1994)

VUM6 interneuron

(Giniger et al., 1994)

Detailed Description

Statement

Reference

In the embryonic CNS, longitudinal connectives are interrupted and commissures fuse. In some segments the VUM neurons are born and differentiate, but fail to form a well-defined posterior root to the anterior peripheral fascicle. Intersegmental nerve shows various aberrations, failing to grow or wandering into adjacent segments, or defasciculation of ISN sensory axons. The lateral chordotonal organs are sometimes displaced dorsally from their wild type position. There is no segment specificity of these phenotypes.

(Giniger et al., 1994)

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Bier et al.

(Giniger et al., 1994)

Comments

Comments

Transposase induced excision of the P element reverts both the lethality and the mutant neuronal phenotype. The ISN phenotype and the lateral chordotonal organ phenotype shows incomplete expressivity. The trachea appear normal in the mutant embryos. The number of PNS neurons, their distribution into neuronal subtypes and differentiation appear normal.

(Giniger et al., 1994)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

lola^2B13

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections